Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 3/20 | 0.38 |
| ▸ | REN | P00797 | 2/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.37 |
| ▸ | ACACB | O00763 | 1/20 | 0.36 |
| ▸ | ACACA | Q13085 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6206334 | 0.83 | MEN1 (0.46) | MAPTBCHEACACBACACA | |
| SCHEMBL6415401 | 0.82 | REN (0.42) | MAPTCTSSRENAAK1 | |
| SCHEMBL6206920 | 0.80 | CTSS (0.41) | MAPTCTSS | |
| SCHEMBL6206021 | 0.78 | CTSS (0.40) | MAPTCTSSRENAAK1 | |
| SCHEMBL6630258 | 0.78 | MAPT (0.39) | MAPTBCHEACHEACACBACACA | |
| SCHEMBL6628525 | 0.77 | CTSK (0.55) | MAPTCTSSACHE | |
| SCHEMBL14345916 | 0.76 | ACACB (0.52) | ACACBACACA | |
| Hydrochloric Acid SCHEMBL7255797 | 0.74 | CTSS (0.47) | CTSSREN | |
| SCHEMBL29025518 | 0.74 | MEN1 (0.45) | MAPTBCHEACACBACACA | |
| SCHEMBL6061712 | 0.74 | MAPT (0.46) | MAPTCTSSBCHEACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1503997-A1 | CYSTEINE PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2005-02-09 | — | — | EP | disclosed |
| WO-2003097617-A1 | CYSTEINE PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2003-11-27 | — | — | WO | disclosed |