Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 5/20 | 0.69 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.69 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.69 |
| ▸ | PTGES | O14684 | 2/20 | 0.69 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Licofelone SCHEMBL237833 | 0.82 | ALOX5 (1.00) | ALOX5PTGS1PTGS2PTGESALOX5AP | |
| SCHEMBL6186052 | 0.82 | ALOX5 (0.58) | ALOX5PTGS1PTGS2PTGESALOX5AP | |
| SCHEMBL6497004 | 0.79 | ALOX5 (1.00) | ALOX5PTGS1PTGS2PTGESALOX5AP | |
| Licofelone SCHEMBL1843506 | 0.78 | PTGES (0.92) | ALOX5PTGS1PTGS2PTGESALOX5AP | |
| Licofelone SCHEMBL1394262 | 0.77 | PTGES (0.84) | ALOX5PTGS1PTGS2PTGESALOX5AP | |
| SCHEMBL8397926 | 0.77 | ALOX5 (0.45) | ALOX5PTGS1PTGS2PTGESALOX5AP | |
| SCHEMBL5554568 | 0.77 | PTGES (0.78) | ALOX5PTGS1PTGS2PTGESALOX5AP | |
| Licofelone SCHEMBL7737421 | 0.77 | PTGES (0.88) | ALOX5PTGS1PTGS2PTGESALOX5AP | |
| SCHEMBL6498829 | 0.76 | ALOX5 (0.77) | ALOX5PTGS1PTGS2PTGESALOX5AP | |
| SCHEMBL6505084 | 0.75 | ALOX5 (0.76) | ALOX5PTGS1PTGS2PTGESALOX5AP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0804437-B1 | [a]-ANNELATED PYRROLE DERIVATIVES AND PHARMACEUTICAL USES THEREOF | MERCKLE GMBH (DE) | 2005-09-14 | — | — | EP | disclosed |
| US-5939415-A | A!-annellated pyrrole derivatives and their use in pharmacology | MERCKLE GMBH (DE) | 1999-08-17 | — | — | US | disclosed |