Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 4/20 | 0.76 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.76 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.64 |
| ▸ | PTGES | O14684 | 2/20 | 0.62 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6498829 | 0.88 | ALOX5 (0.77) | ALOX5PTGS1PTGS2PTGESALOX5AP | |
| SCHEMBL6495009 | 0.86 | ALOX5 (1.00) | ALOX5PTGS1PTGS2PTGESALOX5AP | |
| SCHEMBL6503974 | 0.84 | ALOX5 (0.81) | ALOX5PTGS1PTGS2PTGESALOX5AP | |
| SCHEMBL6506451 | 0.83 | ALOX5 (0.53) | ALOX5PTGS1PTGS2PTGESALOX5AP | |
| SCHEMBL6622141 | 0.78 | ALOX5 (0.52) | ALOX5PTGS1PTGS2PTGESALOX5AP | |
| SCHEMBL6497004 | 0.78 | ALOX5 (1.00) | ALOX5PTGS1PTGS2PTGESALOX5AP | |
| SCHEMBL6499123 | 0.78 | ALOX5 (0.50) | ALOX5PTGS1PTGS2PTGESALOX5AP | |
| Licofelone SCHEMBL237833 | 0.76 | ALOX5 (1.00) | ALOX5PTGS1PTGS2PTGESALOX5AP | |
| SCHEMBL6206054 | 0.75 | ALOX5 (0.69) | ALOX5PTGS1PTGS2PTGESALOX5AP | |
| SCHEMBL5554568 | 0.74 | PTGES (0.78) | ALOX5PTGS1PTGS2PTGESALOX5AP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6878738-B1 | Anti-inflammatory oxo derivatives and hydroxy derivatives of pyrrolizines, and their pharmaceutical use | MERCKLE GMBH (DE) | 2005-04-12 | — | — | US | disclosed |