Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 6/20 | 1.00 |
| ▸ | PTGS1 | P23219 | 6/20 | 1.00 |
| ▸ | PTGS2 | P35354 | 2/20 | 1.00 |
| ▸ | PTGES | O14684 | 2/20 | 0.64 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6505812 | 0.82 | ALOX5 (0.72) | ALOX5PTGS1PTGS2PTGESALOX5AP | |
| SCHEMBL6494104 | 0.81 | ALOX5 (1.00) | ALOX5PTGS1PTGS2PTGESALOX5AP | |
| SCHEMBL6206054 | 0.79 | ALOX5 (0.69) | ALOX5PTGS1PTGS2PTGESALOX5AP | |
| SCHEMBL6496569 | 0.79 | ALOX5 (0.66) | ALOX5PTGS1PTGS2PTGESALOX5AP | |
| Licofelone SCHEMBL237833 | 0.78 | ALOX5 (1.00) | ALOX5PTGS1PTGS2PTGESALOX5AP | |
| SCHEMBL6505084 | 0.78 | ALOX5 (0.76) | ALOX5PTGS1PTGS2PTGESALOX5AP | |
| SCHEMBL6494193 | 0.78 | ALOX5 (0.72) | ALOX5PTGS1PTGS2PTGESALOX5AP | |
| SCHEMBL6626514 | 0.77 | ALOX5 (0.64) | ALOX5PTGS1PTGS2PTGESALOX5AP | |
| SCHEMBL6498829 | 0.76 | ALOX5 (0.77) | ALOX5PTGS1PTGS2PTGESALOX5AP | |
| SCHEMBL5554568 | 0.76 | PTGES (0.78) | ALOX5PTGS1PTGS2PTGESALOX5AP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103172634-A | Method for preparing 6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizinone-5-acetic acid-4'-bromo-butyl ester | TIANJIN INST PHARM RESEARCH | 2013-06-26 | — | — | CN | disclosed |
| US-6878738-B1 | Anti-inflammatory oxo derivatives and hydroxy derivatives of pyrrolizines, and their pharmaceutical use | MERCKLE GMBH (DE) | 2005-04-12 | — | — | US | disclosed |
| EP-1398315-A1 | Anti-inflammatory oxo-derivatives and hydroxy derivatives of pyrrolizines, and their pharmaceutical use | MERCKLE GMBH (DE) | 2004-03-17 | — | — | EP | disclosed |
| WO-2001005792-A9 | ANTI-INFLAMMATORY OXO DERIVATIVES AND HYDROXY DERIVATIVES OF PYRROLIZINES, AND THEIR PHARMACEUTICAL USE | MERCKLE GMBH (DE) | 2002-08-29 | — | — | WO | disclosed |