Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CPN1 | P15169 | 1/20 | 0.35 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.34 |
| ▸ | SLC6A1 | P30531 | 2/20 | 0.33 |
| ▸ | SLC6A11 | P48066 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | SLC6A13 | Q9NSD5 | 1/20 | 0.33 |
| ▸ | APLNR | P35414 | 2/20 | 0.32 |
| ▸ | NOS2 | P35228 | 1/20 | 0.32 |
| ▸ | FPR2 | P25090 | 1/20 | 0.30 |
| ▸ | ARG1 | P05089 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5983633 | 0.74 | CPB2 (0.39) | KDM4EMAPTKMT2AATMCYP2D6 | |
| SCHEMBL7428804 | 0.73 | CPN1 (0.40) | CPN1CPB2EPHX1SLC6A1SLC6A11 | |
| SCHEMBL4769131 | 0.73 | CPN1 (0.40) | CPN1CPB2EPHX1SLC6A1SLC6A11 | |
| SCHEMBL5099315 | 0.71 | ARG1 (0.43) | KDM4EMAPTKMT2AATMCYP2D6 | |
| SCHEMBL5099310 | 0.69 | KDM4E (0.35) | KDM4EMAPTKMT2AATMCYP2D6 | |
| SCHEMBL7428797 | 0.69 | CPN1 (0.38) | MAPTKMT2ACPN1CPB2EPHX1 | |
| SCHEMBL4769110 | 0.68 | CPB2 (0.42) | CPN1CPB2 | |
| SCHEMBL6592080 | 0.68 | PSEN1 (0.37) | KDM4EMAPTKMT2AATMCYP2D6 | |
| SCHEMBL5927975 | 0.67 | EPHX1 (0.61) | KDM4EMAPTEPHX1LMNASMN1; SMN2 | |
| SCHEMBL6503978 | 0.66 | EPHX1 (0.68) | KDM4EMAPTKMT2AATMCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539178-A2 | PROTEASE INHIBITORS | SmithKline Beecham Corporation (US) | 2005-06-15 | — | — | EP | disclosed |
| WO-2004017911-A2 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-03-04 | — | — | WO | disclosed |