Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.41 |
| ▸ | FEN1 | P39748 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6206781 | 0.87 | RAB9A (0.50) | L3MBTL1PKMALDH1A1KDM4ELMNA | |
| SCHEMBL5955449 | 0.82 | TSHR (0.63) | TSHRL3MBTL1ALOX12ERCC5FEN1 | |
| SCHEMBL36590 | 0.75 | TSHR (0.63) | TSHRL3MBTL1ALOX12ERCC5FEN1 | |
| SCHEMBL29566931 | 0.75 | TSHR (0.63) | TSHRL3MBTL1ALOX12ERCC5FEN1 | |
| SCHEMBL6207827 | 0.75 | HPGD (0.52) | TSHRL3MBTL1ALDH1A1KDM4ELMNA | |
| SCHEMBL6208654 | 0.74 | CES2 (0.50) | PKMALDH1A1ATMRAB9AHPGD | |
| SCHEMBL7578668 | 0.74 | TSHR (0.57) | TSHRL3MBTL1ALOX12ERCC5FEN1 | |
| SCHEMBL6207031 | 0.73 | CES2 (0.47) | L3MBTL1PKMALDH1A1LMNARAB9A | |
| SCHEMBL5955453 | 0.73 | TSHR (0.56) | TSHRL3MBTL1ALOX12ERCC5FEN1 | |
| SCHEMBL6205116 | 0.73 | NPC1 (0.50) | PKMALDH1A1LMNARAB9AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1532128-A1 | INHIBITORS OF HCV NS5B POLYMERASE | Pharmacia & Upjohn Company LLC (US) | 2005-05-25 | — | — | EP | disclosed |
| WO-2004002977-A1 | INHIBITORS OF HCV NS5B POLYMERASE | PHARMACIA & UPJOHN COMPANY LLC (US) | 2004-01-08 | — | — | WO | disclosed |