Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | ADORA2A | P29274 | 7/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | BACE1 | P56817 | 2/20 | 0.47 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6206360 | 0.94 | ADORA2A (0.51) | POLBRAB9AADORA2AALDH1A1MEN1 | |
| SCHEMBL6205434 | 0.83 | POLB (0.57) | POLBRAB9ABACE1NPC1SMN1; SMN2 | |
| SCHEMBL6206241 | 0.82 | RAB9A (0.48) | POLBRAB9AADORA2AALDH1A1MEN1 | |
| SCHEMBL6205208 | 0.82 | CHRM3 (0.53) | POLBRAB9AADORA2AALDH1A1MEN1 | |
| SCHEMBL6206374 | 0.80 | ADORA2A (0.58) | POLBRAB9AADORA2AALDH1A1MEN1 | |
| SCHEMBL6205245 | 0.79 | HPGD (0.55) | POLBRAB9AADORA2AALDH1A1NPC1 | |
| SCHEMBL6206694 | 0.79 | WDR5 (0.47) | POLBRAB9AADORA2A | |
| SCHEMBL29050126 | 0.76 | ALDH1A1 (0.60) | POLBRAB9AALDH1A1MEN1KMT2A | |
| SCHEMBL6205349 | 0.75 | NHERF1 (0.65) | POLBADORA2ASMN1; SMN2ADORA1 | |
| SCHEMBL6224870 | 0.75 | CFTR (0.62) | POLBRAB9AADORA2ANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177177-B1 | SUBSTITUTED 4-OXO-QUINOLINE-3-CARBOXAMIDES: GABA BRAIN RECEPTOR LIGANDS | NEUROGEN CORP (US) | 2005-02-23 | — | — | EP | claimed |