Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | TACR1 | P25103 | 2/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 6/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.40 |
| ▸ | DUT | P33316 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.39 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.39 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10123845 | 0.83 | LMNA (0.51) | LMNACHRM3CHRM2CHRM1ALDH1A1 | |
| SCHEMBL8336623 | 0.79 | LMNA (0.56) | LMNACHRM3CHRM2CHRM1DUT | |
| SCHEMBL8336619 | 0.79 | LMNA (0.56) | LMNACHRM3CHRM2CHRM1DUT | |
| SCHEMBL8339280 | 0.79 | LMNA (0.56) | LMNACHRM3CHRM2CHRM1DUT | |
| SCHEMBL6688937 | 0.78 | KDM4E (0.40) | LMNATACR1CHRM3CHRM2CHRM1 | |
| SCHEMBL6264165 | 0.76 | LMNA (0.44) | LMNACHRM3CHRM2CHRM1DUT | |
| SCHEMBL7493746 | 0.76 | KDM4E (0.55) | TACR1ALDH1A1TDP1OPRM1SIGMAR1 | |
| SCHEMBL8735443 | 0.75 | LMNA (0.44) | LMNACHRM3CHRM2CHRM1HTT | |
| SCHEMBL5266516 | 0.74 | LMNA (0.70) | LMNACHRM3CHRM2CHRM1HTT | |
| SCHEMBL20128479 | 0.74 | LMNA (0.51) | LMNAALDH1A1KCNH2HRH1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465631-A4 | PYRIMIDINE A2B SELECTIVE ANTAGONIST COMPOUNDS, THEIR SYNTHESIS AND USE | OSI PHARM INC (US) | 2005-03-30 | — | — | EP | disclosed |
| EP-1465631-A2 | PYRIMIDINE A2B SELECTIVE ANTAGONIST COMPOUNDS, THEIR SYNTHESIS AND USE | OSI Pharmaceuticals, Inc. (US) | 2004-10-13 | — | — | EP | disclosed |
| WO-2003053366-A2 | PYRIMIDINE A2B SELECTIVE ANTAGONIST COMPOUNDS, THEIR SYNTHESIS AND USE | OSI PHARMACEUTICALS, INC. (US) | 2003-07-03 | — | — | WO | disclosed |