Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 2/20 | 0.59 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.59 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.59 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.59 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 6/20 | 0.59 |
| ▸ | NPC1 | O15118 | 6/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.56 |
| ▸ | TP53 | P04637 | 5/20 | 0.56 |
| ▸ | RAB9A | P51151 | 5/20 | 0.56 |
| ▸ | TSHR | P16473 | 3/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | CASP1 | P29466 | 2/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.55 |
| ▸ | MAPT | P10636 | 6/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7483823 | 0.85 | PRKDC (0.74) | PRKDCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL10690677 | 0.84 | PRKDC (0.64) | PRKDCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL50238 | 0.81 | SMN1; SMN2 (0.74) | PRKDCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL2742813 | 0.81 | NPC1 (0.66) | PRKDCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL23014197 | 0.79 | GSK3B (0.51) | HPGDNPC1SMN1; SMN2TP53RAB9A | |
| SCHEMBL9827103 | 0.79 | PRKDC (0.55) | PRKDCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL10759830 | 0.79 | CES2 (0.62) | HPGDNPC1TP53RAB9ATSHR | |
| SCHEMBL14982101 | 0.76 | NPC1 (0.76) | PRKDCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL14982132 | 0.74 | ALDH1A1 (0.61) | PRKDCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL20643538 | 0.74 | PRKDC (0.73) | PRKDCPIK3CDPIK3CAPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050250945-A1 | Triazine compounds as inhibitors of bacterial type III protein secretion systems | JANSSEN PHARMACEUTICA, N.V. (BE) | 2005-11-10 | — | — | US | disclosed |
| US-6881850-B2 | Heterocyclically annellated indenochromene derivatives | RODENSTOCK GMBH (DE) | 2005-04-19 | — | — | US | disclosed |
| EP-1144416-B1 | HETEROCYCLICALLY ANELLATED INDENOCHROMENE DERIVATIVES | RODENSTOCK GMBH (DE) | 2005-03-02 | — | — | EP | disclosed |
| US-20040092743-A1 | Heterocyclically annellated indenochromene derivatives | OPTISCHE WERKE G. RODENSTOCK | 2004-05-13 | — | — | US | disclosed |
| US-6660727-B1 | Photochromic heterocyclically anellated indenochromene compounds | RODENSTOCK GMBH (DE) | 2003-12-09 | — | — | US | disclosed |
| EP-1144416-A1 | HETEROCYCLICALLY ANELLATED INDENOCHROMENE DERIVATIVES | Optische Werke G. Rodenstock (DE) | 2001-10-17 | — | — | EP | disclosed |
| WO-2001034609-A1 | HETEROCYCLICALLY ANELLATED INDENOCHROMENE DERIVATIVES | OPTISCHE WERKE G. RODENSTOCK (DE) | 2001-05-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040092743-A1 | Heterocyclically annellated indenochromene derivatives | ALDH1A2, INF2, CYP1B1 | PRKDC 4262/4885PIK3CD 1798/4885PIK3CA 886/4885 |
| US-20050250945-A1 | Triazine compounds as inhibitors of bacterial type III protein secretion systems | PSMB5, GTF3C3, GTF3C5 | PRKDC 2652/4885PIK3CD 1746/4885PIK3CA 2653/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.