Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 2/20 | 0.42 |
| ▸ | CTSK | P43235 | 3/20 | 0.42 |
| ▸ | HPGDS | O60760 | 2/20 | 0.41 |
| ▸ | CTSL | P07711 | 3/20 | 0.41 |
| ▸ | CTSB | P07858 | 3/20 | 0.41 |
| ▸ | CTSS | P25774 | 3/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | GPR132 | Q9UNW8 | 4/20 | 0.39 |
| ▸ | PTAFR | P25105 | 1/20 | 0.39 |
| ▸ | CTSV | O60911 | 1/20 | 0.39 |
| ▸ | CMKLR2 | P46091 | 1/20 | 0.38 |
| ▸ | CMKLR1 | Q99788 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4041541 | 0.92 | CTSK (0.49) | ACECTSKCTSLCTSSTAAR1 | |
| SCHEMBL4044160 | 0.91 | CTSB (0.37) | ACECTSKCTSBCTSSTAAR1 | |
| SCHEMBL6209046 | 0.86 | CTSK (0.47) | ACECTSKHPGDSCTSLCTSB | |
| SCHEMBL4039023 | 0.85 | CTSK (0.50) | ACECTSKCTSSTAAR1GPR132 | |
| SCHEMBL4044930 | 0.84 | DPP4 (0.38) | SMYD3 | |
| SCHEMBL4047615 | 0.84 | CTSB (0.38) | ACECTSKCTSBCTSSTAAR1 | |
| SCHEMBL6213366 | 0.83 | CTSK (0.42) | CTSKHPGDSCTSLCTSBCTSS | |
| SCHEMBL4041209 | 0.83 | HPGDS (0.39) | ACECTSKHPGDSCTSBCTSS | |
| SCHEMBL4042537 | 0.83 | CTSK (0.49) | ACECTSKCTSLCTSBCTSS | |
| SCHEMBL4041490 | 0.82 | CTSK (0.51) | ACECTSKCTSSSMYD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-A1 | BIOLOGICALLY ACTIVE COMPOUNDS | Amura Therapeutics Limited (GB) | 2005-06-29 | — | — | EP | claimed |
| WO-2004007501-A1 | BIOLOGICALLY ACTIVE COMPOUNDS | AMURA THERAPEUTICS LIMITED (GB) | 2004-01-22 | — | — | WO | claimed |
| EP-1546150-A1 | BIOLOGICALLY ACTIVE COMPOUNDS | Amura Therapeutics Limited (GB) | 2005-06-29 | — | — | EP | disclosed |
| WO-2004007501-A1 | BIOLOGICALLY ACTIVE COMPOUNDS | AMURA THERAPEUTICS LIMITED (GB) | 2004-01-22 | — | — | WO | disclosed |