Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSB | P07858 | 1/20 | 0.37 |
| ▸ | CTSS | P25774 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 1/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | ACE | P12821 | 2/20 | 0.35 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.35 |
| ▸ | GPR132 | Q9UNW8 | 4/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | CMKLR2 | P46091 | 1/20 | 0.35 |
| ▸ | CMKLR1 | Q99788 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4047615 | 0.93 | CTSB (0.38) | CTSBCTSSCTSKACEFKBP1A | |
| SCHEMBL4047882 | 0.91 | F2 (0.36) | CTSBCTSSCTSKEPHX1ACE | |
| SCHEMBL6209419 | 0.91 | ACE (0.42) | CTSBCTSSCTSKACEGPR132 | |
| SCHEMBL4045511 | 0.90 | F2 (0.38) | CTSBCTSSCTSK | |
| SCHEMBL4050328 | 0.90 | SCN9A (0.39) | CTSBCTSSCTSKACEFKBP1A | |
| SCHEMBL4045597 | 0.90 | ACE (0.36) | CTSBCTSSCTSKEPHX1ACE | |
| SCHEMBL4046932 | 0.90 | GPR132 (0.35) | CTSBCTSSCTSKGPR132 | |
| SCHEMBL4043952 | 0.89 | CTSK (0.42) | CTSBCTSSCTSKFKBP1ACHRNA7 | |
| SCHEMBL4043998 | 0.88 | FKBP1A (0.37) | CTSBCTSSCTSKEPHX1FKBP1A | |
| SCHEMBL4042165 | 0.87 | EPHX1 (0.37) | CTSBCTSSCTSKEPHX1ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |