Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSB | P07858 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.37 |
| ▸ | ACE | P12821 | 2/20 | 0.36 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.35 |
| ▸ | BCL2 | P10415 | 1/20 | 0.35 |
| ▸ | ECE1 | P42892 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4050328 | 0.94 | SCN9A (0.39) | CTSBCTSSCTSKGPR132ACE | |
| SCHEMBL4045511 | 0.94 | F2 (0.38) | CTSBCTSSCTSKF2 | |
| SCHEMBL4044160 | 0.93 | CTSB (0.37) | CTSBCTSSCTSKGPR132ACE | |
| SCHEMBL4046868 | 0.90 | ITGB1 (0.37) | CTSBCTSSCTSKGPR132ACE2 | |
| SCHEMBL4043952 | 0.90 | CTSK (0.42) | CTSBCTSSCTSKFKBP1ACHRNA7 | |
| SCHEMBL4043998 | 0.89 | FKBP1A (0.37) | CTSBCTSSCTSKFKBP1ACHRNA7 | |
| SCHEMBL4042529 | 0.89 | BCL2 (0.38) | CTSKGPR132ACETAAR1BCL2 | |
| SCHEMBL4044539 | 0.88 | ITGA4 (0.36) | CTSBCTSSCTSKGPR132ACE | |
| SCHEMBL4042676 | 0.88 | CTSB (0.36) | CTSBCTSSCTSKACEFKBP1A | |
| SCHEMBL4049549 | 0.87 | GPR132 (0.38) | CTSBCTSSCTSKGPR132ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |