Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLD2 | O14939 | 1/20 | 0.36 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 10/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | TGM2 | P21980 | 4/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.32 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6210471 | 0.88 | LMNA (0.40) | DPP4HDAC6NAMPT | |
| SCHEMBL6209503 | 0.87 | DPP4 (0.41) | DPP4DRD2DRD3 | |
| SCHEMBL6211156 | 0.85 | CHRM4 (0.41) | DPP4DRD2DRD4DRD3HDAC1 | |
| SCHEMBL6210990 | 0.84 | DPP4 (0.38) | PLD2PLD1DPP4DRD2DRD4 | |
| SCHEMBL5941964 | 0.82 | PKM (0.38) | DPP4DRD3NAMPT | |
| SCHEMBL6209845 | 0.80 | DPP4 (0.30) | DPP4 | |
| SCHEMBL6210886 | 0.79 | DPP4 (0.37) | PLD2PLD1DPP4DRD2DRD4 | |
| SCHEMBL6211236 | 0.75 | PTAFR (0.40) | PLD2PLD1DRD2DRD3HDAC1 | |
| SCHEMBL6209350 | 0.75 | NAMPT (0.40) | PLD2PLD1DPP4DRD2DRD4 | |
| SCHEMBL6210045 | 0.74 | DPP4 (0.46) | DPP4HDAC1HDAC8TMEM97 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-A1 | BIOLOGICALLY ACTIVE COMPOUNDS | Amura Therapeutics Limited (GB) | 2005-06-29 | — | — | EP | disclosed |
| WO-2004007501-A1 | BIOLOGICALLY ACTIVE COMPOUNDS | AMURA THERAPEUTICS LIMITED (GB) | 2004-01-22 | — | — | WO | disclosed |