Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 5/20 | 0.42 |
| ▸ | MMP13 | P45452 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CCR5 | P51681 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6210327 | 0.93 | GAA (0.45) | CHRM4POLBHPGDCCR5GAA | |
| SCHEMBL6210258 | 0.91 | POLB (0.42) | CHRM4MMP13POLBHPGDCCR5 | |
| SCHEMBL6210874 | 0.91 | ALDH1A1 (0.40) | CHRM4MMP13POLBHPGDCTSK | |
| SCHEMBL6211027 | 0.90 | NAMPT (0.40) | CHRM4POLBHPGDCCR5CTSK | |
| SCHEMBL6209043 | 0.90 | LMNA (0.41) | POLBCCR5CTSKLMNASMN1; SMN2 | |
| SCHEMBL6212088 | 0.89 | SLC6A5 (0.40) | CHRM4CCR5CTSKLMNAHTT | |
| SCHEMBL6259636 | 0.88 | HDAC3 (0.35) | CHRM4POLBHPGDCTSKLMNA | |
| SCHEMBL6213867 | 0.88 | CHRM4 (0.40) | CHRM4MMP13POLBHPGDCCR5 | |
| SCHEMBL6211167 | 0.87 | CTSK (0.39) | HPGDCTSKKMT2AHTTSMN1; SMN2 | |
| SCHEMBL6212722 | 0.87 | CHRM4 (0.43) | CHRM4MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-A1 | BIOLOGICALLY ACTIVE COMPOUNDS | Amura Therapeutics Limited (GB) | 2005-06-29 | — | — | EP | claimed |
| WO-2004007501-A1 | BIOLOGICALLY ACTIVE COMPOUNDS | AMURA THERAPEUTICS LIMITED (GB) | 2004-01-22 | — | — | WO | claimed |
| EP-1546150-A1 | BIOLOGICALLY ACTIVE COMPOUNDS | Amura Therapeutics Limited (GB) | 2005-06-29 | — | — | EP | disclosed |
| WO-2004007501-A1 | BIOLOGICALLY ACTIVE COMPOUNDS | AMURA THERAPEUTICS LIMITED (GB) | 2004-01-22 | — | — | WO | disclosed |