Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8340434 | 0.87 | MAPT (0.43) | MAPTNPSR1ALDH1A1HPGDHTT | |
| SCHEMBL14260875 | 0.87 | MAPT (0.43) | MAPTNPSR1ALDH1A1HPGDHTT | |
| SCHEMBL8342702 | 0.87 | L3MBTL1 (0.52) | LMNAMAPTALDH1A1HPGDMEN1 | |
| SCHEMBL6190192 | 0.87 | L3MBTL1 (0.52) | LMNAMAPTALDH1A1HPGDMEN1 | |
| SCHEMBL6212321 | 0.86 | ALDH1A1 (0.45) | LMNAMAPTALDH1A1HPGDMEN1 | |
| SCHEMBL3359038 | 0.81 | LMNA (0.47) | LMNAMAPTNPSR1ALDH1A1HPGD | |
| SCHEMBL7288753 | 0.77 | ALDH1A1 (0.48) | LMNAMAPTNPSR1ALDH1A1HPGD | |
| SCHEMBL3343328 | 0.76 | HSPB1 (0.41) | LMNAMAPTALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL14260873 | 0.76 | MAPT (0.43) | MAPTNPSR1ALDH1A1HPGDHTT | |
| SCHEMBL8340048 | 0.76 | MAPT (0.43) | MAPTNPSR1ALDH1A1HPGDHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101443014-A | Compound (I) | ASTRAZENECA AB (SE) | 2009-05-27 | — | — | CN | disclosed |
| EP-1554250-A1 | NOVEL LACTAMS AND USES THEREOF | AstraZeneca AB (SE) | 2005-07-20 | — | — | EP | disclosed |
| WO-2004031154-A1 | NOVEL LACTAMS AND USES THEREOF | ASTRAZENECA AB (SE) | 2004-04-15 | — | — | WO | disclosed |