Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 11/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 9/20 | 0.36 |
| ▸ | VDR | P11473 | 2/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 2/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6210811 | 0.85 | CHRM4 (0.40) | DPP4DRD3DRD2 | |
| SCHEMBL6210064 | 0.84 | CHRM2 (0.39) | HDAC3HDAC1DPP4DRD3DRD2 | |
| SCHEMBL6262865 | 0.83 | HDAC3 (0.45) | HDAC3HDAC1HDAC8VDRDRD3 | |
| SCHEMBL6210241 | 0.83 | ROCK2 (0.36) | HDAC3HDAC1HDAC8DPP4HDAC6 | |
| SCHEMBL6213828 | 0.82 | CTSK (0.57) | CTSK | |
| SCHEMBL6209065 | 0.80 | HDAC1 (0.43) | HDAC3HDAC1HDAC8DRD3DRD2 | |
| SCHEMBL6210861 | 0.79 | HDAC1 (0.41) | HDAC3HDAC1HDAC8DRD3HDAC6 | |
| SCHEMBL6209349 | 0.77 | — | — | |
| SCHEMBL6259546 | 0.74 | ALDH1A1 (0.46) | HDAC3HDAC1DRD3DRD2 | |
| SCHEMBL6213962 | 0.74 | CTSK (0.41) | CTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-A1 | BIOLOGICALLY ACTIVE COMPOUNDS | Amura Therapeutics Limited (GB) | 2005-06-29 | — | — | EP | disclosed |
| WO-2004007501-A1 | BIOLOGICALLY ACTIVE COMPOUNDS | AMURA THERAPEUTICS LIMITED (GB) | 2004-01-22 | — | — | WO | disclosed |