Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6578925 | 1.00 | LMNA (0.40) | LMNAALDH1A1THRBMAPTATM | |
| SCHEMBL9529967 | 0.76 | — | — | |
| SCHEMBL3386110 | 0.74 | — | — | |
| SCHEMBL6836741 | 0.73 | CHRM2 (0.41) | LMNAALDH1A1 | |
| Oxirane SCHEMBL11531139 | 0.73 | ALDH1A1 (0.35) | LMNAALDH1A1 | |
| SCHEMBL11237163 | 0.70 | — | — | |
| SCHEMBL6419144 | 0.70 | USP2 (0.41) | LMNAALDH1A1MAPT | |
| SCHEMBL11681867 | 0.70 | — | — | |
| Glycerin SCHEMBL830352 | 0.67 | — | — | |
| Glycerin SCHEMBL3943790 | 0.67 | LMNA (0.64) | LMNAALDH1A1THRBMAPTATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1216053-C | 2,2-disubstituted 1,3,-dioxolanes as antitussive agents | DOMPE SPA (IT) | 2005-08-24 | — | — | CN | claimed |
| US-6916926-B2 | Process for the preparation of (±) 1-3-dioxolanes and the optical resolution thereof | DOMPE S.P.A. (IT) | 2005-07-12 | — | — | US | claimed |
| CN-1204135-C | 1, 3-dioxolanes with antitussive activity | DOMPE SPA (IT) | 2005-06-01 | — | — | CN | claimed |
| EP-1307440-B1 | 2,2-DISUBSTITUTED 1,3-DIOXOLANES AS ANTITUSSIVE AGENTS | DOMPE SPA (IT) | 2005-03-09 | — | — | EP | claimed |
| CN-1444579-A | 2, 2-disubstituted 1, 3-dioxolanes as antitussives | DOMPE SPA (IT) | 2003-09-24 | — | — | CN | claimed |
| CN-1444578-A | 1, 3-dioxolanes with antitussive activity | DOMPE SPA (IT) | 2003-09-24 | — | — | CN | claimed |
| US-20030176446-A1 | 2,2-disubstituted 1,3-dioxolanes as antitussive agents | DOMPÉ FARMACEUTICI S.P.A. (IT) | 2003-09-18 | — | — | US | claimed |
| EP-1307440-A1 | 2,2-DISUBSTITUTED 1,3-DIOXOLANES AS ANTITUSSIVE AGENTS | Dompe' S.P.A. (IT) | 2003-05-07 | — | — | EP | claimed |
| WO-2002010150-A1 | 2,2-DISUBSTITUTED 1,3-DIOXOLANES AS ANTITUSSIVE AGENTS | DOMPE' S.P.A. (IT) | 2002-02-07 | — | — | WO | claimed |
| CN-1216053-C | 2,2-disubstituted 1,3,-dioxolanes as antitussive agents | DOMPE SPA (IT) | 2005-08-24 | — | — | CN | disclosed |
| US-6916926-B2 | Process for the preparation of (±) 1-3-dioxolanes and the optical resolution thereof | DOMPE S.P.A. (IT) | 2005-07-12 | — | — | US | disclosed |
| CN-1204135-C | 1, 3-dioxolanes with antitussive activity | DOMPE SPA (IT) | 2005-06-01 | — | — | CN | disclosed |
| EP-1307440-B1 | 2,2-DISUBSTITUTED 1,3-DIOXOLANES AS ANTITUSSIVE AGENTS | DOMPE SPA (IT) | 2005-03-09 | — | — | EP | disclosed |
| US-6835734-B2 | (S)-3-(4-Phenyl-1-piperazinyl)-1,2-propanediol cyclic acetals, useful as intermediates for the preparation of levodropropizine | Dompé S.p.A. (IT) | 2004-12-28 | — | — | US | disclosed |
| CN-1444578-A | 1, 3-dioxolanes with antitussive activity | DOMPE SPA (IT) | 2003-09-24 | — | — | CN | disclosed |
| US-20030176446-A1 | 2,2-disubstituted 1,3-dioxolanes as antitussive agents | DOMPÉ FARMACEUTICI S.P.A. (IT) | 2003-09-18 | — | — | US | disclosed |
| EP-1307440-A1 | 2,2-DISUBSTITUTED 1,3-DIOXOLANES AS ANTITUSSIVE AGENTS | Dompe' S.P.A. (IT) | 2003-05-07 | — | — | EP | disclosed |
| EP-1307441-A1 | 1,3-DIOXOLANES WITH ANTITUSSIVE ACTIVITY | Dompe' S.P.A. (IT) | 2003-05-07 | — | — | EP | disclosed |
| WO-2002010150-A1 | 2,2-DISUBSTITUTED 1,3-DIOXOLANES AS ANTITUSSIVE AGENTS | DOMPE' S.P.A. (IT) | 2002-02-07 | — | — | WO | disclosed |
| WO-2002010149-A1 | 1,3-DIOXOLANES WITH ANTITUSSIVE ACTIVITY | DOMPE' S.P.A. (IT) | 2002-02-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030176446-A1 | 2,2-disubstituted 1,3-dioxolanes as antitussive agents | ADRB2, QDPR, ADRB3 | LMNA 3401/4885ALDH1A1 295/4885THRB 1109/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.