Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 1/20 | 0.31 |
| ▸ | PNMT | P11086 | 1/20 | 0.31 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.31 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8766370 | 0.61 | PNMT (0.35) | ADRA2APNMTADRA2BADRA2C | |
| SCHEMBL5420448 | 0.60 | PDE3B (0.39) | ADRA2APNMTADRA2BADRA2C | |
| SCHEMBL13960939 | 0.58 | MAPT (0.45) | ADRA2APNMTADRA2BADRA2C | |
| SCHEMBL8765334 | 0.57 | CA1 (0.36) | ADRA2APNMTADRA2BADRA2C | |
| SCHEMBL20180555 | 0.57 | KDM4E (0.64) | ADRA2C | |
| SCHEMBL5213966 | 0.56 | NOTUM (0.35) | — | |
| SCHEMBL18454733 | 0.56 | — | — | |
| SCHEMBL25044261 | 0.56 | ALDH1A1 (0.58) | — | |
| SCHEMBL16506973 | 0.56 | TRIM24 (0.49) | — | |
| SCHEMBL13960940 | 0.55 | NOTUM (0.47) | ADRA2APNMTADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2603218-A1 | QUINOLYL AMINES AS KINASE INHIBITORS | GlaxoSmithKline Intellectual Property Development Limited (GB) | 2013-06-19 | — | — | EP | disclosed |
| WO-2012021580-A1 | QUINOLYL AMINES AS KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2012-02-16 | — | — | WO | disclosed |