Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PIR | O00625 | 1/20 | 0.37 |
| ▸ | MMP3 | P08254 | 2/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6966789 | 0.83 | ALDH1A1 (0.49) | ALDH1A1ATMCYP1A2CYP3A4BCHE | |
| SCHEMBL9614028 | 0.81 | MMP2 (0.51) | ALDH1A1GAAPKMLMNAAR | |
| SCHEMBL1307134 | 0.77 | CA2 (0.48) | ALDH1A1GAAATMCYP1A2CYP3A4 | |
| SCHEMBL29956354 | 0.76 | MCHR1 (0.44) | ALDH1A1GAALMNACYP3A4CA12 | |
| SCHEMBL186606 | 0.76 | CA12 (0.43) | ALDH1A1GAALMNACYP3A4CA12 | |
| SCHEMBL8607431 | 0.76 | ALDH1A1 (0.42) | ALDH1A1GAAPKMLMNAAR | |
| SCHEMBL31106589 | 0.74 | MCHR1 (0.47) | ALDH1A1GAALMNAATMCYP3A4 | |
| SCHEMBL30828010 | 0.74 | ALDH1A1 (0.43) | ALDH1A1GAALMNACYP3A4CA12 | |
| SCHEMBL31106597 | 0.74 | MCHR1 (0.47) | ALDH1A1GAALMNAATMCYP3A4 | |
| SCHEMBL2246161 | 0.74 | ALDH1A1 (0.49) | ALDH1A1GAAPKMLMNAAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1549635-A1 | 3,4-DISUBSTITUTED PYRROLES AND THEIR FOR USE IN TREATING INFLAMMATORY DISEASES | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-07-06 | — | — | EP | disclosed |
| US-20050043331-A1 | Substituted 3-(2,5-disubstituted)pyridyl-4-aryl pyrroles for treating inflammatory diseases | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-02-24 | — | — | US | disclosed |
| WO-2004029040-A1 | 3,4-DISUBSTITUTED PYRROLES AND THEIR FOR USE IN TREATING INFLAMMATORY DISEASES | JANSSEN PHARMACEUTICA N.V. (BE) | 2004-04-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050043331-A1 | Substituted 3-(2,5-disubstituted)pyridyl-4-aryl pyrroles for treating inflammatory diseases | TNF, TSLP, IRAK1 | ALDH1A1 1528/4885GAA 2159/4885PKM 960/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.