Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 11/20 | 0.51 |
| ▸ | MMP9 | P14780 | 10/20 | 0.51 |
| ▸ | MMP3 | P08254 | 2/20 | 0.48 |
| ▸ | MMP13 | P45452 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9613904 | 0.90 | MMP2 (0.53) | MMP2MMP9MMP3MMP13LMNA | |
| SCHEMBL10420695 | 0.82 | MMP2 (0.55) | MMP2MMP9MMP3MMP13ALDH1A1 | |
| SCHEMBL872842 | 0.82 | MMP9 (0.56) | MMP2MMP9LMNAMAPTALDH1A1 | |
| SCHEMBL9614226 | 0.81 | MMP2 (0.52) | MMP2MMP9MMP3MMP13LMNA | |
| SCHEMBL10419465 | 0.81 | MMP2 (0.54) | MMP2MMP9MMP3MMP13ALDH1A1 | |
| SCHEMBL10420884 | 0.81 | MMP2 (0.54) | MMP2MMP9MMP3MMP13ALDH1A1 | |
| SCHEMBL10420440 | 0.81 | MMP2 (0.54) | MMP2MMP9MMP3MMP13ALDH1A1 | |
| SCHEMBL6220362 | 0.81 | ALDH1A1 (0.42) | MMP2MMP9MMP3LMNAMAPT | |
| SCHEMBL9614324 | 0.81 | MMP2 (0.46) | MMP2MMP9MMP3MMP13LMNA | |
| SCHEMBL9858481 | 0.80 | MMP2 (0.53) | MMP2MMP9MMP3MMP13LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5145611-A | Diabetes | BOEHRINGER MANNHEIM GMBH (DE) | 1992-09-08 | — | — | US | disclosed |
| EP-0279162-B1 | CARBONIC ACID DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICALS CONTAINING THEM | Roche Diagnostics GmbH (DE) | 1991-06-19 | — | — | EP | disclosed |
| EP-0279162-A1 | Carbonic acid derivatives, process for their preparation and pharmaceuticals containing them | Roche Diagnostics GmbH (DE) | 1988-08-24 | — | — | EP | disclosed |