Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 14/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 14/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 14/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 10/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7966598 | 0.85 | HTR2C (0.46) | HTR1ASLC6A2SLC6A4MEN1KMT2A | |
| SCHEMBL7964862 | 0.77 | JUND (0.39) | HTR1ASLC6A2SLC6A4SLC6A3MEN1 | |
| SCHEMBL6220551 | 0.77 | SLC6A2 (0.40) | HTR1ASLC6A2SLC6A4SLC6A3SLC18A3 | |
| SCHEMBL1545124 | 0.75 | KDM4E (0.49) | HTR1AMEN1KMT2ASLC18A3SIGMAR1 | |
| Hydrochloric Acid SCHEMBL1838069 | 0.74 | KDM4E (0.51) | HTR1AMEN1KMT2ASLC18A3SIGMAR1 | |
| SCHEMBL8474378 | 0.72 | DRD2 (0.44) | HTR1A | |
| SCHEMBL24330092 | 0.72 | HTR1A (0.41) | HTR1ASLC6A2SLC6A4SLC6A3MEN1 | |
| SCHEMBL7962541 | 0.71 | MKNK1 (0.33) | — | |
| SCHEMBL6665906 | 0.71 | HTR1A (0.44) | HTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL1545776 | 0.71 | CYP1A2 (0.41) | HTR1ASLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546143-A1 | HETEROCYCLIC SUBSTITUTED PIPERAZINES FOR THE TREATMENT OF SCHIZOPHRENIA | Warner-Lambert Company LLC (US) | 2005-06-29 | — | — | EP | disclosed |
| WO-2004026864-A1 | HETEROCYCLIC SUBSTITUTED PIPERAZINES FOR THE TREATMENT OF SCHIZOPHRENIA | WARNER-LAMBERT COMPANY LLC (US) | 2004-04-01 | — | — | WO | disclosed |
| US-6420390-B1 | ANALGESIC AGENTS | AVENTIS PHARMACEUTICALS INC. | 2002-07-16 | — | — | US | disclosed |