Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 1/20 | 0.44 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | CES1 | P23141 | 2/20 | 0.35 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | TRPM4 | Q8TD43 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.34 |
| ▸ | EDNRB | P24530 | 1/20 | 0.34 |
| ▸ | EDNRA | P25101 | 1/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12648428 | 0.81 | NOTUM (0.50) | HPGDSLTA4HHCRTR1HCRTR2CYP3A4 | |
| SCHEMBL28164766 | 0.81 | HPGDS (0.46) | HPGDSLTA4HHCRTR1HCRTR2CYP3A4 | |
| SCHEMBL1804513 | 0.81 | PRKCI (0.53) | HPGDSLTA4HHCRTR1HCRTR2CYP3A4 | |
| SCHEMBL9863754 | 0.81 | HPGDS (0.46) | HPGDSLTA4HHCRTR1HCRTR2CYP3A4 | |
| SCHEMBL9454674 | 0.81 | HPGDS (0.46) | HPGDSLTA4HHCRTR1HCRTR2CYP3A4 | |
| SCHEMBL6850862 | 0.80 | LTA4H (0.47) | HPGDSLTA4HCES1KCNJ1KCNH2 | |
| SCHEMBL9507339 | 0.79 | HPGDS (0.53) | HPGDSLTA4HHCRTR1HCRTR2CYP3A4 | |
| SCHEMBL3964365 | 0.79 | HPGDS (0.58) | HPGDSLTA4HNOTUMBRD4TRPM4 | |
| SCHEMBL15652074 | 0.78 | HPGDS (0.46) | HPGDSLTA4HBRD4HDAC4BACE1 | |
| SCHEMBL16383003 | 0.77 | HPGDS (0.43) | HPGDSLTA4HHCRTR1HCRTR2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539757-A1 | SUBSTITUTED PYRROLOPYRIDINES | AstraZeneca AB (SE) | 2005-06-15 | — | — | EP | disclosed |
| WO-2004016609-A1 | SUBSTITUTED PYRROLOPYRIDINES | ASTRAZENECA AB (SE) | 2004-02-26 | — | — | WO | disclosed |