Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 1/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.45 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | HRH1 | P35367 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MLYCD | O95822 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15903903 | 0.82 | MLYCD (0.38) | MLYCDNPC1RAB9ASMN1; SMN2MAPK1 | |
| SCHEMBL28134248 | 0.81 | KMT2A (0.54) | ALDH1A1ATMPOLBHSD17B10 | |
| SCHEMBL30059761 | 0.81 | KMT2A (0.54) | ALDH1A1ATMPOLBHSD17B10 | |
| SCHEMBL9461917 | 0.79 | HPGD (0.49) | PGRADRA2AADRA2BHTR2AHRH1 | |
| SCHEMBL9461916 | 0.79 | HPGD (0.49) | PGRADRA2AADRA2BHTR2AHRH1 | |
| SCHEMBL8174284 | 0.78 | ALDH1A1 (0.46) | PGRADRA2AADRA2BHTR2AHRH1 | |
| SCHEMBL1004360 | 0.78 | MLYCD (0.62) | PGRADRA2AADRA2BHTR2AHRH1 | |
| SCHEMBL1003650 | 0.77 | NAMPT (0.55) | PGRADRA2AADRA2BHTR2AHRH1 | |
| SCHEMBL23791942 | 0.76 | HTR1A (0.46) | PGRADRA2AADRA2BHTR2AHRH1 | |
| SCHEMBL4842545 | 0.75 | TRPM8 (0.43) | TRPM8ALDH1A1POLBBRD4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1581491-A1 | INDOLE DERIVATIVES AS PPAR MODULATORS | ELI LILLY AND COMPANY (US) | 2005-10-05 | — | — | EP | disclosed |
| WO-2004092131-A1 | INDOLE DERIVATIVES AS PPAR MODULATORS | ELI LILLY AND COMPANY (US) | 2004-10-28 | — | — | WO | disclosed |