Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 5/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.37 |
| ▸ | BRD4 | O60885 | 4/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6223610 | 0.75 | PGR (0.45) | TRPM8POLBBRD4TSHRALDH1A1 | |
| SCHEMBL29129627 | 0.74 | LMNA (0.44) | TRPM8LMNAPOLBNR1I2OPRD1 | |
| SCHEMBL29172976 | 0.73 | ALDH1A1 (0.46) | TRPM8LMNAOPRD1TSHRALDH1A1 | |
| SCHEMBL4845270 | 0.71 | GAA (0.39) | LMNAPOLBCYP2C19ALDH1A1 | |
| SCHEMBL1004360 | 0.71 | MLYCD (0.62) | OPRD1ALDH1A1 | |
| SCHEMBL8174284 | 0.71 | ALDH1A1 (0.46) | TRPM8LMNAAOC3ALDH1A1 | |
| SCHEMBL29173001 | 0.71 | KMT2A (0.50) | LMNATSHRALDH1A1 | |
| SCHEMBL9474075 | 0.71 | TSHR (0.41) | TRPM8LMNAPOLBOPRD1TSHR | |
| SCHEMBL1003650 | 0.70 | NAMPT (0.55) | ALDH1A1 | |
| SCHEMBL23791942 | 0.69 | HTR1A (0.46) | TRPM8LMNAPOLBTSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7342007-B2 | Lactams and uses thereof | ASTRAZENECA AB (SE) | 2008-03-11 | — | — | US | disclosed |
| US-20060183732-A1 | Novel lactams and uses thereof | ASTRAZENECA AB (SE) | 2006-08-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060183732-A1 | Novel lactams and uses thereof | BACE1, BACE2, APP | TRPM8 4410/4885LMNA 2273/4885AOC3 2357/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.