Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 11/20 | 0.48 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28429634 | 0.78 | HTR7 (0.39) | DRD2DRD4DRD3SLC6A3 | |
| SCHEMBL11017734 | 0.78 | SLC6A3 (0.35) | CYP19A1SLC6A3 | |
| SCHEMBL8104816 | 0.76 | CYP19A1 (0.54) | CYP19A1DRD2DRD4DRD3SLC6A3 | |
| SCHEMBL9194497 | 0.76 | CYP19A1 (0.54) | CYP19A1DRD2DRD4DRD3SLC6A3 | |
| SCHEMBL6179732 | 0.74 | SLC6A3 (0.33) | CYP19A1SLC6A3 | |
| SCHEMBL6224183 | 0.74 | ALDH1A1 (0.40) | SLC6A3 | |
| SCHEMBL3421080 | 0.74 | AOC3 (0.36) | — | |
| SCHEMBL6983001 | 0.74 | AOC3 (0.48) | CYP19A1TAAR1 | |
| SCHEMBL2320532 | 0.73 | TAAR1 (0.62) | CYP19A1TAAR1 | |
| SCHEMBL10574057 | 0.73 | TAAR1 (0.62) | CYP19A1TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1411942-A4 | SUBSTITUTED ANILINIC PIPERIDINES AS MCH SELECTIVE ANTAGONISTS | SYNAPTIC PHARMA CORP (US) | 2005-01-26 | — | — | EP | disclosed |
| EP-1411942-A1 | SUBSTITUTED ANILINIC PIPERIDINES AS MCH SELECTIVE ANTAGONISTS | Synaptic Pharmaceutical Corporation (US) | 2004-04-28 | — | — | EP | disclosed |
| WO-2003004027-A1 | SUBSTITUTED ANILINIC PIPERIDINES AS MCH SELECTIVE ANTAGONISTS | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 2003-01-16 | — | — | WO | disclosed |
| EP-0144729-A1 | 11-Substituted 5H,11H-pyrrolo[2,1-c][1,4]benzoxazepines, a process for their preparation and their use in medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1985-06-19 | — | — | EP | disclosed |