SCHEMBL8104816

SCHEMBL8104816

N#Cc1ccc(C(Cl)CCc2ccc(F)cc2)cc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 9/20 0.54
MAOA P21397 1/20 0.46
MAOB P27338 1/20 0.46
EPHX2 P34913 1/20 0.43
SLC1A2 P43004 1/20 0.42
KCNH2 Q12809 1/20 0.42
CACNA1F O60840 2/20 0.42
HTR1A P08908 2/20 0.42
ADORA3 P0DMS8 2/20 0.42
DRD2 P14416 2/20 0.42
DRD1 P21728 2/20 0.42
DRD4 P21917 2/20 0.42
DRD5 P21918 2/20 0.42
HRH2 P25021 2/20 0.42
ADRA1D P25100 2/20 0.42
HTR2A P28223 2/20 0.42
HTR7 P34969 2/20 0.42
ADRA1A P35348 2/20 0.42
HRH1 P35367 2/20 0.42
ADRA1B P35368 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9194497 1.00 CYP19A1 (0.54) CYP19A1MAOAMAOBEPHX2SLC1A2
SCHEMBL8109000 0.81 CYP19A1 (0.54) CYP19A1MAOAMAOBEPHX2SLC1A2
SCHEMBL6225909 0.76 CYP19A1 (0.48) CYP19A1DRD2DRD4DRD3SLC6A3
SCHEMBL8411721 0.76 MAOA (0.58) CYP19A1MAOAMAOBKCNH2CYP11B1
SCHEMBL11566011 0.72 LOXL2 (0.54) CYP19A1MAOAMAOBKCNH2MMP12
SCHEMBL8408602 0.72 CYP19A1 (0.52) CYP19A1MAOAMAOBEPHX2CACNA1F
SCHEMBL7935598 0.72 MAOA (0.61) CYP19A1MAOAMAOBKCNH2CYP11B1
SCHEMBL10667759 0.71 MMP12 (0.53) CYP19A1KCNH2MMP12MMP13
SCHEMBL17857729 0.71 TSHR (0.62) CYP19A1MAOAMAOBKCNH2CYP11B1
SCHEMBL8408610 0.71 CYP19A1 (0.54) CYP19A1EPHX2CACNA1FHTR1AADORA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0674626-B1 SELECTIVE AROMATASE INHIBITING COMPOUNDS RISTO ARVO SAKARI LAMMINTAUSTA (FI) 2000-07-19 EP disclosed
US-5962495-A ESTROGEN SENSITIVE DISEASES; BREAST CANCER; PROSTATE TUMORS RISTO ARVO SAKARI LAMMINTAUSTA (FI) 1999-10-05 US disclosed
US-5703109-A CYANOPHENYL-1,2,4-TRIAZOLE DERIVATIVE Oy, Orion-yhtyma (FI) 1997-12-30 US disclosed
EP-0674626-A1 NOVEL SELECTIVE AROMATASE INHIBITING COMPOUNDS ORION-YHTYMÄ OY (FI) 1995-10-04 EP disclosed
WO-1994013645-A1 NOVEL SELECTIVE AROMATASE INHIBITING COMPOUNDS Orion-Yhtymä Oy (FI) 1994-06-23 WO disclosed