SCHEMBL6226136

SCHEMBL6226136

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nearest known ligand 0.39

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
PDE4A P27815 1/20 0.32
LMNA P02545 2/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
TDP1 Q9NUW8 1/20 0.31
USP2 O75604 1/20 0.31
SLCO1B1 Q9Y6L6 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6228481 0.87 MAPT (0.36) PDE4ALMNAL3MBTL1
Acetone SCHEMBL28329344 0.84 MAPT (0.34) LMNA
SCHEMBL17767399 0.84 PAX8 (0.38) PDE4ALMNAL3MBTL1USP2SLCO1B1
SCHEMBL9225414 0.82 MAPT (0.53) LMNA
SCHEMBL9227207 0.82 MAPT (0.53) LMNA
SCHEMBL4606284 0.81
SCHEMBL5448988 0.81 PDE4A (0.31) PDE4ALMNAL3MBTL1
SCHEMBL16144867 0.80 PDE4A (0.40) PDE4ALMNAL3MBTL1TDP1USP2
SCHEMBL28085202 0.79 USP2 (0.36) PDE4ALMNAL3MBTL1TDP1USP2
SCHEMBL5685647 0.79 USP2 (0.36) PDE4ALMNAL3MBTL1TDP1USP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20050058611-A1 Preventing and/or combating collagen fiber degradation induced under conditions of natural exposure to sunlight L'OREAL (FR) 2005-03-17 US disclosed
EP-1508328-A1 Composition against the degradation of fibres of collagen induced in condition of natural solar exposure L'OREAL (FR) 2005-02-23 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050058611-A1 Preventing and/or combating collagen fiber degradation induced under conditions of natural exposure to sunlight COL14A1, COL2A1, COL1A1 PDE4A 2732/4885LMNA 176/4885L3MBTL1 4595/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.