SCHEMBL622757

SCHEMBL622757

CC(C)C(CC=CCl)(C(=O)O)C(=O)O

nearest known ligand 0.33

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GRIK1 P39086 1/20 0.32
GRIK2 Q13002 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL622756 1.00 GRIK1 (0.32) GRIK1GRIK2
SCHEMBL14425429 0.83
SCHEMBL2108417 0.78 GRIK1 (0.31) GRIK1GRIK2
SCHEMBL295881 0.78 GRIK1 (0.31) GRIK1GRIK2
SCHEMBL11139699 0.75
SCHEMBL8847968 0.74 TSHR (0.38)
SCHEMBL2233286 0.67 ALDH1A1 (0.33)
SCHEMBL9978452 0.66 DGAT1 (0.38)
SCHEMBL10907823 0.66 ALDH1A1 (0.32)
SCHEMBL21269713 0.66 ALDH1A1 (0.32)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1571138-B2 PROCESSES FOR PRODUCING (4E)-5-CHLORO-2-ISOPROPYL-4-PENTENOIC ESTER AND OPTICALLY ACTIVE ISOMER THEREOF ASAHI GLASS CO LTD (JP) 2014-12-17 EP disclosed
WO-2012021446-A2 PROCESS FOR PREPARING ALISKIREN AND ITS INTERMEDIATES DR. REDDY'S LABORATORIES LTD. (IN) 2012-02-16 WO disclosed
US-7232925-B2 Process for producing (4E)-5-chloro-2-isopropyl-4-pentenoate and optically active form thereof ASAHI GLASS COMPANY, LIMITED (JP) 2007-06-19 US disclosed
EP-1571138-B1 PROCESSES FOR PRODUCING (4E)-5-CHLORO-2-ISOPROPYL-4-PENTENOIC ESTER AND OPTICALLY ACTIVE ISOMER THEREOF ASAHI GLASS CO LTD (JP) 2007-02-28 EP disclosed
US-20050228193-A1 Process for producing (4E)-5-chloro-2-isopropyl-4-pentenoate and optically active form thereof ASAHI GLASS COMPANY LIMITED (JP) 2005-10-13 US disclosed
EP-1571138-A1 PROCESSES FOR PRODUCING (4E)-5-CHLORO-2-ISOPROPYL-4-PENTENOIC ESTER AND OPTICALLY ACTIVE ISOMER THEREOF ASAHI GLASS COMPANY LTD. (JP) 2005-09-07 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050228193-A1 Process for producing (4E)-5-chloro-2-isopropyl-4-pentenoate and optically active form thereof C5, ALOX5, PTGER4 GRIK1 2747/4885GRIK2 2313/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.