Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCA | P17252 | 3/20 | 0.63 |
| ▸ | PARP1 | P09874 | 2/20 | 0.57 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.44 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.44 |
| ▸ | GABRP | O00591 | 1/20 | 0.42 |
| ▸ | GABRD | O14764 | 1/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.42 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.42 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.42 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.42 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.42 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.42 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.42 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.42 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.42 |
| ▸ | GABRE | P78334 | 1/20 | 0.42 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.42 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.42 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.42 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5828670 | 0.83 | PARP1 (0.59) | PRKCAPARP1IMPDH2IMPDH1GABRP | |
| SCHEMBL5828276 | 0.79 | PARP1 (0.51) | PRKCAPARP1IMPDH2IMPDH1GABRP | |
| SCHEMBL8317372 | 0.78 | PRKCA (1.00) | PRKCAMAPTCDK4CCND1KMT2A | |
| SCHEMBL25835901 | 0.77 | PARP1 (0.68) | PRKCAPARP1IMPDH2IMPDH1GABRP | |
| SCHEMBL25835900 | 0.77 | PARP1 (0.68) | PRKCAPARP1IMPDH2IMPDH1GABRP | |
| SCHEMBL9622806 | 0.76 | NQO1 (0.67) | PRKCAPARP1MAPTKDM4EALDH1A1 | |
| SCHEMBL9622936 | 0.73 | TERT (0.52) | PARP1MAPTPOLBKDM4EALDH1A1 | |
| SCHEMBL6214537 | 0.73 | PARP1 (0.62) | PRKCAPARP1IMPDH2IMPDH1GABRP | |
| SCHEMBL10014083 | 0.73 | PARP1 (0.62) | PRKCAPARP1IMPDH2IMPDH1GABRP | |
| SCHEMBL29516962 | 0.73 | PARP1 (1.00) | PRKCAPARP1MAPTCDK4CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501831-A1 | INHIBITORS OF CHECKPOINT KINASES (WEE1 AND CHK1) | WARNER-LAMBERT COMPANY LLC (US) | 2005-02-02 | — | — | EP | claimed |
| WO-2003091255-A1 | INHIBITORS OF CHECKPOINT KINASES (WEE1 AND CHK1) | WARNER-LAMBERT COMPANY LLC (US) | 2003-11-06 | — | — | WO | claimed |