SCHEMBL8317372

SCHEMBL8317372

O=C1c2c(c3c4ccccc4[nH]c3c3[nH]c4ccccc4c23)C(=O)N1O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PRKCA P17252 5/20 1.00
CDK4 P11802 9/20 0.62
CCND1 P24385 9/20 0.62
CAMK2B Q13554 7/20 0.62
CAMK2G Q13555 7/20 0.62
CAMK2D Q13557 7/20 0.62
CAMK2A Q9UQM7 7/20 0.62
CCNE2 O96020 5/20 0.62
CCNE1 P24864 5/20 0.62
CDK2 P24941 5/20 0.62
PRKACA P17612 4/20 0.62
PRKACG P22612 4/20 0.62
PRKACB P22694 4/20 0.62
PRKD3 O94806 3/20 0.62
PRKCG P05129 3/20 0.62
PRKCB P05771 3/20 0.62
PRKCH P24723 3/20 0.62
PRKCI P41743 3/20 0.62
PRKCE Q02156 3/20 0.62
PRKCQ Q04759 3/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5438544 0.83 PRKCA (0.71) PRKCACDK4CCND1CAMK2BCAMK2G
SCHEMBL8318191 0.80 PRKCA (0.67) PRKCACDK4CCND1CAMK2BCAMK2G
SCHEMBL6229657 0.78 PRKCA (0.63) PRKCACDK4CCND1CAMK2BCAMK2G
SCHEMBL31237530 0.77 CDK4 (0.61) PRKCACDK4CCND1CAMK2BCAMK2G
Staurosporine Aglycon SCHEMBL29406635 0.77 CDK4 (1.00) PRKCACDK4CCND1CAMK2BCAMK2G
Staurosporine Aglycon SCHEMBL30530825 0.77 CDK4 (1.00) PRKCACDK4CCND1CAMK2BCAMK2G
Staurosporine Aglycon SCHEMBL8124103 0.77 CDK4 (1.00) PRKCACDK4CCND1CAMK2BCAMK2G
SCHEMBL8313203 0.76 NQO1 (1.00) PRKCACDK4CCND1CAMK2BCAMK2G
SCHEMBL14708732 0.73 ROCK2 (0.58) PRKCACDK4CCND1CAMK2BCAMK2G
SCHEMBL6080907 0.73 PRKCA (0.57) PRKCACDK4CCND1CAMK2BCAMK2G

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0630242-B1 FURTHER INDOLE DERIVATIVES WITH ANTIVIRAL ACTIVITY WELLCOME FOUND (GB) 1999-01-20 EP claimed