Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | ELANE | P08246 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2948314 | 0.78 | KDM4E (0.38) | ALDH1A1SMN1; SMN2HSD17B10LMNAKDM4E | |
| SCHEMBL6015870 | 0.76 | ALDH1A1 (0.54) | ALDH1A1SMN1; SMN2CYP1A2CYP2C19HSD17B10 | |
| SCHEMBL6015950 | 0.73 | KMT2A (0.50) | ALDH1A1LMNAKDM4EMAPT | |
| SCHEMBL6015705 | 0.73 | MEN1 (0.41) | ALDH1A1HSD17B10NPSR1 | |
| SCHEMBL9581979 | 0.72 | — | — | |
| SCHEMBL5497340 | 0.72 | ALDH1A1 (0.34) | ALDH1A1SMN1; SMN2CYP1A2HSD17B10LMNA | |
| SCHEMBL27467119 | 0.71 | KMT2A (0.56) | ALDH1A1SMN1; SMN2CYP1A2CYP2C19LMNA | |
| SCHEMBL9582187 | 0.70 | ALDH1A1 (0.43) | ALDH1A1SMN1; SMN2CYP1A2HSD17B10LMNA | |
| SCHEMBL6236614 | 0.69 | SLC9A1 (0.37) | ALDH1A1HSD17B10LMNAKDM4EPOLB | |
| SCHEMBL3209745 | 0.69 | NOTUM (0.47) | ALDH1A1SMN1; SMN2HSD17B10LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1595866-B1 | Cyanopyrrolidines useful for the treatment of inter alia metabolic syndrome | SANWA KAGAKU KENKYUSHO CO (JP) | 2016-06-08 | — | — | EP | disclosed |
| CN-100434420-C | Compounds that block dipeptidyl peptidase IV | SANWA KAGAKU KENKYUSHO CO (JP) | 2008-11-19 | — | — | CN | disclosed |
| CN-1745063-A | Compound inhibiting dipeptidyl peptidase iv | SANWA KAGAKU KENKYUSHO CO (JP) | 2006-03-08 | — | — | CN | disclosed |
| EP-1595866-A1 | COMPOUND INHIBITING DIPEPTIDYL PEPTIDASE IV | Sanwa Kagaku Kenkyusho Co., Ltd. (JP) | 2005-11-16 | — | — | EP | disclosed |