Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 14/20 | 0.71 |
| ▸ | CA1 | P00915 | 13/20 | 0.71 |
| ▸ | ACHE | P22303 | 8/20 | 0.69 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.60 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5857443 | 0.90 | CA2 (0.64) | CA2CA1ACHEPTGS1PTGS2 | |
| SCHEMBL5858805 | 0.90 | PTGS1 (0.60) | CA2CA1ACHEPTGS1PTGS2 | |
| SCHEMBL6560048 | 0.90 | PTGS1 (0.60) | CA2CA1ACHEPTGS1PTGS2 | |
| SCHEMBL5856299 | 0.84 | L3MBTL1 (0.71) | CA2CA1PTGS1PTGS2 | |
| SCHEMBL6230120 | 0.80 | PTGS2 (0.66) | CA2CA1ACHEPTGS1PTGS2 | |
| SCHEMBL6560885 | 0.80 | PTGS2 (0.66) | CA2CA1ACHEPTGS1PTGS2 | |
| SCHEMBL5857939 | 0.79 | PTGS1 (0.64) | PTGS1PTGS2 | |
| SCHEMBL5856560 | 0.78 | PTGS1 (0.49) | CA2CA1ACHEPTGS1PTGS2 | |
| SCHEMBL5856792 | 0.78 | PTGS1 (0.63) | PTGS1PTGS2 | |
| SCHEMBL5857642 | 0.78 | PTGS1 (0.63) | PTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1516621-A2 | Use of pyrazoline derivatives in the preparation of a medicament for the prevention and/or treatment of cell proliferation diseases | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2005-03-23 | — | — | EP | claimed |
| EP-1083171-B1 | PYRAZOLINE DERIVATIVES, THEIR PREPARATION AND APPLICATION AS MEDICAMENTS | ESTEVE LABOR DR (ES) | 2004-04-28 | — | — | EP | claimed |
| US-20040034082-A1 | Utilization of pyrazoline derivatives in the preparation of a medicament for the prevention and/or treatment of proliferative cell diseases | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2004-02-19 | — | — | US | claimed |
| EP-1384477-A1 | UTILIZATION OF PYRAZOLINE DERIVATIVES IN THE PREPARATION OF A MEDICAMENT FOR THE PREVENTION AND/OR TREATMENT OF PROLIFERATIVE CELL DISEASES | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2004-01-28 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040034082-A1 | Utilization of pyrazoline derivatives in the preparation of a medicament for the prevention and/or treatment of proliferative cell diseases | VHL, MET, PRMT1 | CA2 1414/4885CA1 911/4885ACHE 3821/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.