Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.43 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.41 |
| ▸ | ACACB | O00763 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18923563 | 0.93 | HSD17B10 (0.53) | TSHRHSD17B10ALDH1A1SIGMAR1 | |
| SCHEMBL8875728 | 0.88 | TRPV4 (0.46) | TSHRHSD17B10NPC1HPGDRAB9A | |
| SCHEMBL10334702 | 0.85 | HSD17B10 (0.46) | TSHRHSD17B10NPC1HPGDRAB9A | |
| SCHEMBL12188756 | 0.83 | CYP2A6 (0.47) | TSHRHPGDNPSR1ALDH1A1SIGMAR1 | |
| SCHEMBL19122600 | 0.83 | HSD17B10 (0.49) | TSHRHSD17B10SMN1; SMN2ALDH1A1SIGMAR1 | |
| SCHEMBL24267634 | 0.81 | HSD17B10 (0.51) | TSHRHSD17B10ALDH1A1SIGMAR1 | |
| SCHEMBL8875503 | 0.81 | HSD17B10 (0.51) | TSHRHSD17B10ALDH1A1SIGMAR1 | |
| SCHEMBL11127882 | 0.81 | NPC1 (0.50) | TSHRHSD17B10NPC1HPGDRAB9A | |
| SCHEMBL28826019 | 0.80 | HSD17B10 (0.53) | TSHRHSD17B10HPGDALDH1A1 | |
| SCHEMBL9177318 | 0.79 | SIGMAR1 (0.62) | SMN1; SMN2ALDH1A1SKP2SIGMAR1GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015055293-A1 | METHOD FOR THE PREPARATION OF 1,2-BENZISOTHIAZOLIN-3-ONES | THOR GMBH (DE) | 2015-04-23 | — | — | WO | disclosed |
| EP-2687520-A1 | METHOD FOR PRODUCING 1,2-BENZISOTHIAZOL-3-ONE COMPOUND | Sumitomo Seika Chemicals Co., Ltd. (JP) | 2014-01-22 | — | — | EP | disclosed |
| US-20130345434-A1 | METHOD FOR PRODUCING 1,2-BENZISOTHIAZOL-3-ONE COMPOUND | SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) | 2013-12-26 | — | — | US | disclosed |
| EP-1081141-B1 | Method for producing 1,2-benzisothiazol-3-ones | SUMITOMO SEIKA CHEMICALS (JP) | 2005-05-04 | — | — | EP | disclosed |
| EP-1081141-A1 | Method for producing 1,2-benzisothiazol-3-ones | SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) | 2001-03-07 | — | — | EP | disclosed |
| US-5773626-A | HALOGENATION OF A 2-(ALKYLTHIO)BENZALDEHYDE OXIME | SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) | 1998-06-30 | — | — | US | disclosed |
| US-5633384-A | FROM O-ALKYLTHIOBENZONITRILES | SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) | 1997-05-27 | — | — | US | disclosed |
| EP-0702008-A2 | Method for producing 1,2-benzisothiazol-3-ones | SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) | 1996-03-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130345434-A1 | METHOD FOR PRODUCING 1,2-BENZISOTHIAZOL-3-ONE COMPOUND | TST, SOAT1, BZW2 | TSHR 2160/4885HSD17B10 679/4885NPC1 1457/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.