Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.31 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.31 |
| ▸ | SYK | P43405 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6230455 | 0.98 | — | — | |
| SCHEMBL6229873 | 0.70 | — | — | |
| SCHEMBL606580 | 0.67 | — | — | |
| SCHEMBL281998 | 0.67 | — | — | |
| SCHEMBL2956791 | 0.67 | — | — | |
| SCHEMBL6234352 | 0.67 | — | — | |
| SCHEMBL12289411 | 0.66 | — | — | |
| SCHEMBL2643645 | 0.66 | — | — | |
| SCHEMBL2644167 | 0.66 | — | — | |
| SCHEMBL2644166 | 0.66 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1626525-A | Process for the preparation of thiazole derivatives | SYNGENTA CROP PROT INC (CH) | 2005-06-15 | — | — | CN | disclosed |
| EP-1202979-B1 | PROCESS FOR THE PREPARATION OF THIAZOLE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2005-04-27 | — | — | EP | disclosed |
| EP-1313747-B1 | METHOD FOR PRODUCING ALKYL-BRIDGED LIGAND SYSTEMS AND TRANSITION METAL COMPOUNDS | BASELL POLYOLEFINE GMBH (DE) | 2005-04-20 | — | — | EP | disclosed |
| CN-1169800-C | Process for preparing thiazole derivatives | �����ɷ� | 2004-10-06 | — | — | CN | disclosed |
| US-6710182-B2 | REACTING 5-HYDROXYMETHYLTHIAZOLE-DIAZONIUM SALT WITH HYDROGEN HALIDE OR MINERAL ACID; CHLORINATION, DESALTING, DEHYDROXYLATION | SYNGENTA CROP PROTECTION, INC. | 2004-03-23 | — | — | US | disclosed |
| US-20030191321-A1 | PROCESS FOR THE PREPARATION OF THIAZOLE DERIVATIVES | COPPOLA KEVIN (US) | 2003-10-09 | — | — | US | disclosed |
| US-6566530-B2 | Preparing 2-chloro-5-chloromethylthiazole by reacting 2-hydroxy-5-hydroxymethylthiazole with a chloride anion source in the presence of an acid. | SYNGENTA CROP PROTECTION, INC. | 2003-05-20 | — | — | US | disclosed |
| US-20030055229-A1 | Process for the preparation of thiazole derivatives | COPPOLA KEVIN (US) | 2003-03-20 | — | — | US | disclosed |
| US-6476230-B1 | Process for the preparation of thiazole derivatives | SYNGENTA CROP PROTECTION, INC. | 2002-11-05 | — | — | US | disclosed |
| CN-1368966-A | Process for preparing thiazole derivatives | SYNGENTA PARTICIPATIONS AG (CH) | 2002-09-11 | — | — | CN | disclosed |
| EP-1202979-A1 | PROCESS FOR THE PREPARATION OF THIAZOLE DERIVATIVES | Syngenta Participations AG (CH) | 2002-05-08 | — | — | EP | disclosed |
| US-6265553-B1 | INTERMEDIATES FOR INSECTICIDES | SYNGENTA CROP PROTECTION, INC. | 2001-07-24 | — | — | US | disclosed |
| WO-2001010852-A1 | PROCESS FOR THE PREPARATION OF THIAZOLE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2001-02-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030055229-A1 | Process for the preparation of thiazole derivatives | DDT, CYP3A5, CYP3A4 | CYP2A6 57/4885SRC 1958/4885ZAP70 1991/4885 |
| US-20030191321-A1 | PROCESS FOR THE PREPARATION OF THIAZOLE DERIVATIVES | DDT, CYP3A5, CYP3A4 | CYP2A6 57/4885SRC 1958/4885ZAP70 1991/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.