Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 5/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | MMP8 | P22894 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9712251 | 0.78 | MMP8 (0.52) | POLBNPSR1NPC1KMT2AMEN1 | |
| SCHEMBL4298143 | 0.78 | POLB (0.51) | POLBNPSR1NPC1KMT2AMEN1 | |
| SCHEMBL12121920 | 0.78 | POLB (0.66) | POLBNPSR1NPC1KMT2AMEN1 | |
| SCHEMBL14394147 | 0.77 | ALDH1A1 (0.55) | NPC1KMT2AMEN1HDAC3HDAC4 | |
| SCHEMBL164403 | 0.76 | POLB (0.49) | POLBNPSR1NPC1KMT2AMEN1 | |
| SCHEMBL1464689 | 0.74 | PIN1 (0.50) | POLBNPSR1NPC1KMT2AMEN1 | |
| SCHEMBL29492080 | 0.74 | POLB (0.69) | POLBNPSR1NPC1KMT2AMEN1 | |
| SCHEMBL6228327 | 0.74 | POLB (0.54) | POLBNPSR1NPC1KMT2AMEN1 | |
| SCHEMBL9874568 | 0.73 | ALDH1A1 (0.39) | KMT2AMEN1ALDH1A1MMP8MAPT | |
| SCHEMBL5963640 | 0.73 | POLB (0.64) | POLBNPSR1NPC1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1525177-A1 | SUBSTITUTED 1,3-DIPHENYLPROP-2-EN-1-ONE DERIVATIVES AND PREPARATION AND USES THEREOF | Genfit (FR) | 2005-04-27 | — | — | EP | disclosed |
| WO-2004005233-A1 | SUBSTITUTED 1,3-DIPHENYLPROP-2-EN-1-ONE DERIVATIVES AND PREPARATION AND USES THEREOF | GENFIT (FR) | 2004-01-15 | — | — | WO | disclosed |