Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.41 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PTGES | O14684 | 2/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6465588 | 1.00 | ERN1 (0.43) | ERN1GAASMN1; SMN2CYSLTR2CYSLTR1 | |
| SCHEMBL6465591 | 0.90 | ERN1 (0.42) | ERN1GAASMN1; SMN2CYSLTR2CYSLTR1 | |
| SCHEMBL6237455 | 0.89 | MAPT (0.42) | ERN1SMN1; SMN2CYSLTR2CYSLTR1POLB | |
| SCHEMBL6459325 | 0.89 | ALDH1A1 (0.42) | ERN1GAASMN1; SMN2CYSLTR2CYSLTR1 | |
| SCHEMBL7643417 | 0.85 | ERN1 (0.38) | ERN1GAASMN1; SMN2CYSLTR2CYSLTR1 | |
| SCHEMBL14707709 | 0.82 | PPARG (0.44) | GAASMN1; SMN2PTGESALOX5PPARG | |
| SCHEMBL2330339 | 0.81 | PPARA (0.44) | PTGESALOX5PPARGALDH1A1MAPT | |
| SCHEMBL2547539 | 0.81 | PTGDR2 (0.51) | ERN1SMN1; SMN2CYSLTR2CYSLTR1POLB | |
| SCHEMBL2562538 | 0.80 | ERN1 (0.46) | ERN1POLBALDH1A1MAPTCYP2D6 | |
| SCHEMBL15332076 | 0.79 | ERN1 (0.50) | ERN1SMN1; SMN2ALDH1A1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1222159-B1 | INTERMEDIATES FOR MAKING A BENZOFURAN OR BENZOTHIOPHENE DERIVATIVE NITRATED IN POSITION 5 AND USES THEREOF | RHODIA CHIMIE SA (FR) | 2005-06-01 | — | — | EP | claimed |
| US-6855842-B1 | Intermediates for making a bezofuran or benzothiophene derivative nitrated in position 5 and uses thereof | RHODIA CHIMIE (FR) | 2005-02-15 | — | — | US | claimed |
| CN-101948455-B | Preparation method of 2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran | SHANDONG ZOUPING DAZHAN NEW MATERIAL CO LTD | 2012-11-14 | — | — | CN | disclosed |
| CN-101948455-A | Preparation method of 2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran | SHANDONG ZOUPING DAZHAN NEW MATERIAL CO LTD | 2011-01-19 | — | — | CN | disclosed |
| CN-101948454-A | Method for preparing 2-butyl-5-nitrobenzofuran | SHANDONG ZOUPING DAZHAN NEW MATERIAL CO LTD | 2011-01-19 | — | — | CN | disclosed |
| US-7312345-B2 | Process for the preparation of dronedarone | ISP INVESTMENTS INC. (US) | 2007-12-25 | — | — | US | disclosed |
| EP-1222159-B1 | INTERMEDIATES FOR MAKING A BENZOFURAN OR BENZOTHIOPHENE DERIVATIVE NITRATED IN POSITION 5 AND USES THEREOF | RHODIA CHIMIE SA (FR) | 2005-06-01 | — | — | EP | disclosed |
| US-20050113596-A1 | Nitrating a 2-(2-formylphenoxy) or 2-(2-formylphenylsulfido) alkyl ester or alkoic acid in the presence of sulfuric acid | SHASUN PHARMA SOLUTIONS, INC. | 2005-05-26 | — | — | US | disclosed |
| US-6855842-B1 | Intermediates for making a bezofuran or benzothiophene derivative nitrated in position 5 and uses thereof | RHODIA CHIMIE (FR) | 2005-02-15 | — | — | US | disclosed |
| EP-1222181-B1 | METHOD FOR PREPARING A BENZOFURAN OR BENZOTHIOPHENE COMPOUND | RHODIA CHIMIE SA (FR) | 2003-12-10 | — | — | EP | disclosed |
| US-6555697-B1 | Cyclizing a 1-(2-carboxyethyloxy or thio-),2-formylbenzene in the presence of an efficient amount of a carbonate base in a medium comprising a carboxylic acid anhydride; intermediate for 2-n-butyl-5-nitrobenzofuran | RHODIA CHIMIE (FR) | 2003-04-29 | — | — | US | disclosed |
| JP-2002255954-A | METHOD FOR PRODUCING 2-n-BUTYL-5-NITROBENZOFURAN | ISHINO YOSHIO | 2002-09-11 | — | — | JP | disclosed |
| EP-1222159-A2 | INTERMEDIATES FOR MAKING A BENZOFURAN OR BENZOTHIOPHENE DERIVATIVE NITRATED IN POSITION 5 AND USES THEREOF | RHODIA CHIMIE (FR) | 2002-07-17 | — | — | EP | disclosed |
| EP-1222181-A1 | METHOD FOR PREPARING A BENZOFURAN OR BENZOTHIOPHENE COMPOUND | RHODIA CHIMIE (FR) | 2002-07-17 | — | — | EP | disclosed |
| WO-2001029019-A1 | METHOD FOR PREPARING A BENZOFURAN OR BENZOTHIOPHENE COMPOUND | RHODIA CHIMIE (FR) | 2001-04-26 | — | — | WO | disclosed |
| WO-2001028974-A2 | INTERMEDIATES FOR MAKING A BENZOFURAN OR BENZOTHIOPHENE DERIVATIVE NITRATED IN POSITION 5 AND USES THEREOF | RHODIA CHIMIE (FR) | 2001-04-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050113596-A1 | Nitrating a 2-(2-formylphenoxy) or 2-(2-formylphenylsulfido) alkyl ester or alkoic acid in the presence of sulfuric acid | SULT1A1, SULT1E1, FPR1 | ERN1 1853/4885GAA 3152/4885SMN1; SMN2 2443/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.