Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.45 |
| ▸ | YWHAG | P61981 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA3 | P07451 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CA6 | P23280 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5776297 | 0.95 | CYP1A2 (0.41) | SMN1; SMN2CYP1A2NPC1MAPTRAB9A | |
| SCHEMBL13034170 | 0.85 | CYP1A2 (0.53) | SMN1; SMN2CYP1A2NPC1MAPTRAB9A | |
| SCHEMBL5626293 | 0.85 | LOXL2 (0.49) | SMN1; SMN2NPC1RAB9ATP53CYP3A4 | |
| SCHEMBL5691933 | 0.84 | LOXL2 (0.47) | SMN1; SMN2NPC1MAPTRAB9AKDM4E | |
| SCHEMBL14070437 | 0.84 | CYP1A2 (0.45) | SMN1; SMN2CYP1A2NPC1MAPTRAB9A | |
| Hydrochloric Acid SCHEMBL27558956 | 0.84 | CYP1A2 (0.51) | SMN1; SMN2CYP1A2NPC1MAPTRAB9A | |
| Hydrochloric Acid SCHEMBL27502508 | 0.84 | NOS1 (0.47) | SMN1; SMN2NPC1RAB9ATP53CYP3A4 | |
| Hydrochloric Acid SCHEMBL27521374 | 0.83 | NOS1 (0.46) | SMN1; SMN2NPC1RAB9ATP53CYP3A4 | |
| SCHEMBL27558951 | 0.83 | MAOA (0.44) | SMN1; SMN2CYP1A2NPC1MAPTRAB9A | |
| SCHEMBL13422217 | 0.80 | PPARA (0.48) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004089903-A9 | PIPERIDINE DERIVATIVES AS RENIN INHIBITORS FOR THE TREATMENT OF HYPERTENSION | WARNER LAMBERT CO (US) | 2005-10-27 | — | — | WO | disclosed |
| US-20040204455-A1 | Piperidine derivative rennin inhibitors | WARNER-LAMBERT COMPANY LLC | 2004-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040204455-A1 | Piperidine derivative rennin inhibitors | REN, ACE, HPN | SMN1; SMN2 4290/4885CYP1A2 2821/4885NPC1 3866/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.