Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 19/20 | 0.43 |
| ▸ | MMP1 | P03956 | 17/20 | 0.43 |
| ▸ | MMP3 | P08254 | 2/20 | 0.43 |
| ▸ | MMP9 | P14780 | 2/20 | 0.43 |
| ▸ | MMP13 | P45452 | 7/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6237935 | 0.87 | MMP1 (0.52) | ADAM17MMP1MMP3MMP9MMP13 | |
| SCHEMBL6238179 | 0.87 | MMP1 (0.54) | ADAM17MMP1MMP3MMP9MMP13 | |
| SCHEMBL6241133 | 0.87 | MMP1 (0.54) | ADAM17MMP1MMP3MMP9MMP13 | |
| SCHEMBL6238727 | 0.87 | MMP1 (0.54) | ADAM17MMP1MMP3MMP9MMP13 | |
| SCHEMBL6238194 | 0.86 | MMP1 (0.55) | ADAM17MMP1MMP3MMP9MMP13 | |
| SCHEMBL7130071 | 0.86 | ADAM17 (0.55) | ADAM17MMP1MMP3MMP9MMP13 | |
| SCHEMBL6237324 | 0.86 | ADAM17 (0.55) | ADAM17MMP1MMP3MMP9MMP13 | |
| SCHEMBL6240990 | 0.84 | MMP1 (0.57) | ADAM17MMP1MMP3MMP9MMP13 | |
| SCHEMBL6239527 | 0.84 | ADAM17 (0.46) | ADAM17MMP1MMP3MMP9MMP13 | |
| SCHEMBL6240212 | 0.84 | MMP1 (0.51) | ADAM17MMP1MMP3MMP9MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1104412-B1 | TACE INHIBITORS | PFIZER PROD INC (US) | 2005-06-15 | — | — | EP | claimed |