Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | CCL2 | P13500 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31046607 | 1.00 | HTR2A (0.43) | HTR2AHTR6KDM4ECYP2D6TP53 | |
| SCHEMBL23100802 | 0.80 | HTR2A (0.36) | HTR2AHTR6KDM4ECYP2D6TP53 | |
| SCHEMBL25218430 | 0.78 | HTR2A (0.39) | HTR2AHTR6KDM4ECYP2D6TP53 | |
| SCHEMBL3246033 | 0.78 | HTR2A (0.35) | HTR2AHTR6KDM4ECYP2D6BRD4 | |
| SCHEMBL8732534 | 0.77 | HTR2A (0.38) | HTR2AHTR6KDM4ECYP2D6TP53 | |
| SCHEMBL9309445 | 0.77 | HTR2A (0.38) | HTR2AHTR6KDM4ECYP2D6TP53 | |
| SCHEMBL31068436 | 0.77 | HTR6 (0.41) | HTR2AHTR6KDM4ECYP2D6TP53 | |
| SCHEMBL8380997 | 0.77 | HTR2A (0.38) | HTR2AHTR6KDM4ECYP2D6TP53 | |
| SCHEMBL8380915 | 0.77 | HTR2A (0.38) | HTR2AHTR6KDM4ECYP2D6TP53 | |
| SCHEMBL8383845 | 0.77 | HTR2A (0.38) | HTR2AHTR6KDM4ECYP2D6TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115057831-B | Thiadiazole compound and application thereof in preparation of KKBC 1 protein inhibitor | 中国医科大学附属盛京医院 | 2023-08-04 | — | — | CN | claimed |
| CN-115057831-A | Thiadiazole compound and application thereof in preparation of KKLC1 protein inhibitor | 中国医科大学附属盛京医院 | 2022-09-16 | — | — | CN | claimed |
| CN-1307064-A | Monocyclopentadienes catalyst for polymerization of olefin and preparaing method thereof | CHINESE ACAD INST CHEMISTRY (CN) | 2001-08-08 | — | — | CN | claimed |
| CN-115362151-B | Arylpiperidines as monoacylglycerol lipase modulators | 詹森药业有限公司 | 2025-02-11 | — | — | CN | disclosed |
| US-20240092781-A1 | ARYL PIPERIDINES AS MONOACYLGLYCEROL LIPASE MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2024-03-21 | — | — | US | disclosed |
| US-11787798-B2 | Aryl piperidines as monoacylglycerol lipase modulators | JANSSEN PHARMACEUTICA NV (BE) | 2023-10-17 | — | — | US | disclosed |
| CN-111630083-B | Polyamide composition comprising specific copolyamide containing caprolactam monomer, semi-crystalline polyamide and reinforcing filler | 巴斯夫欧洲公司 | 2023-09-01 | — | — | CN | disclosed |
| CN-115612271-B | Heat-resistant flame-retardant PC (polycarbonate) reinforced material and production method thereof | 江苏松上科技有限公司 | 2023-08-08 | — | — | CN | disclosed |
| CN-115057831-B | Thiadiazole compound and application thereof in preparation of KKBC 1 protein inhibitor | 中国医科大学附属盛京医院 | 2023-08-04 | — | — | CN | disclosed |
| CN-114262492-B | Heat-resistant flame-retardant ABS material and production method thereof | 江苏松上科技有限公司 | 2023-04-11 | — | — | CN | disclosed |
| CN-115612271-A | Heat-resistant flame-retardant PC (polycarbonate) reinforced material and production method thereof | 江苏松上科技有限公司 | 2023-01-17 | — | — | CN | disclosed |
| CN-103022376-A | Organic light-emitting diode (OLED) device | KUNSHAN VISIONOX DISPLAY TECH | 2013-04-03 | — | — | CN | disclosed |
| CN-102010353-A | New method for preparing rasagiline mesylate | WINCHEM SCIENCE AND TECHNOLOGY CO LTD | 2011-04-13 | — | — | CN | disclosed |
| CN-101381314-A | Preparation method of (R)-(+)-N-propargyl-1-indan amines | CHENGDU HEALTHCARE PHARMACEUTI (CN) | 2009-03-11 | — | — | CN | disclosed |
| US-6936636-B2 | 5-[phenyl-tetrahydronaphthalene-2-yl dihydronaphthalen-2-yl and heteroaryl-cyclopropyl]-pentadienoic acid derivatives having serum glucose reducing activity | ALLERGAN, INC. (US) | 2005-08-30 | — | — | US | disclosed |
| CN-1653021-A | Preparation of substituted indenes | BASELL POLYOLEFINE GMBH (DE) | 2005-08-10 | — | — | CN | disclosed |
| WO-2005000784-A2 | 5-[PHENYL, TETRAHYDRONAPHTHALENE-2-YL DIHYDRONAPHTHALEN-2-YL AND HETEROARYL- CYCLOPROPYL]-PENTADIENOIC ACID DERIVATIVES HAVING SERUM GLUCOSE REDUCING ACTIVITY | ALLERGAN, INC. (US) | 2005-01-06 | — | — | WO | disclosed |
| US-20050004213-A1 | 5-[phenyl-tetrahydronaphthalene-2-yl dihydronaphthalen-2-yl and heteroaryl-cyclopropyl]-pentadienoic acid derivatives having serum glucose reducing activity | ALLERGAN, INC. | 2005-01-06 | — | — | US | disclosed |
| CN-1307064-A | Monocyclopentadienes catalyst for polymerization of olefin and preparaing method thereof | CHINESE ACAD INST CHEMISTRY (CN) | 2001-08-08 | — | — | CN | disclosed |
| EP-0258096-A2 | Indane derivatives, process for their preparation, their use as medicines, pharmaceutical compositions containing them and the intermediates obtained | ROUSSEL-UCLAF (FR) | 1988-03-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240092781-A1 | ARYL PIPERIDINES AS MONOACYLGLYCEROL LIPASE MODULATORS | MGLL, LPL, PNLIP | HTR2A 26/4885HTR6 281/4885KDM4E 1995/4885 |
| US-11787798-B2 | Aryl piperidines as monoacylglycerol lipase modulators | MGLL, LPL, PNLIP | HTR2A 26/4885HTR6 281/4885KDM4E 1995/4885 |
| US-20050004213-A1 | 5-[phenyl-tetrahydronaphthalene-2-yl dihydronaphthalen-2-yl and heteroaryl-cyclopropyl]-pentadienoic acid derivatives having serum glucose reducing activity | PNLIP, TPO, MTTP | HTR2A 1227/4885HTR6 1480/4885KDM4E 3712/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.