SCHEMBL623398

SCHEMBL623398

COc1ccccc1C(N[C@H](CS)C(=O)O)(c1ccccc1)c1ccccc1

nearest known ligand 0.39

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.39
GAA P10253 4/20 0.39
KMT2A Q03164 3/20 0.38
MEN1 O00255 2/20 0.38
ITGA4 P13612 2/20 0.37
ITGAV P06756 1/20 0.37
ITGB7 P26010 1/20 0.37
ITGB1 P05556 1/20 0.36
AKR1C3 P42330 1/20 0.36
AKR1C2 P52895 1/20 0.36
ATM Q13315 1/20 0.36
POLB P06746 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
NPC1 O15118 1/20 0.36
FPR2 P25090 1/20 0.36
KIF11 P52732 1/20 0.36
KCNN4 O15554 1/20 0.36
SHMT2 P34897 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1487611 1.00 ALDH1A1 (0.39) ALDH1A1GAAKMT2AMEN1ITGA4
SCHEMBL28273157 0.88 L3MBTL1 (0.40) ALDH1A1GAAKMT2AMEN1ATM
SCHEMBL28130590 0.88 L3MBTL1 (0.40) ALDH1A1GAAKMT2AMEN1ATM
SCHEMBL2558020 0.86 ALDH1A1 (0.40) ALDH1A1GAAKMT2AMEN1ITGA4
SCHEMBL20191077 0.82 MMP2 (0.42) ALDH1A1GAAKIF11
SCHEMBL8682774 0.82 NPSR1 (0.44) SMN1; SMN2
SCHEMBL232516 0.82 NPSR1 (0.44) SMN1; SMN2
SCHEMBL232515 0.82 NPSR1 (0.44) SMN1; SMN2
SCHEMBL4970029 0.82 KIF11 (0.49) ALDH1A1KMT2ANPC1FPR2KIF11
SCHEMBL18249991 0.81 ACE (0.37) ALDH1A1ITGA4ITGB7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018165575-A2 WARHEAD-CONTAINING PEPTIDOMIMETIC MACROCYCLES AS MODULATORS OF BFL-1 AILERON THERAPEUTICS, INC. (US) 2018-09-13 WO disclosed
WO-2017004548-A1 PEPTIDOMIMETIC MACROCYCLES AILERON THERAPEUTICS, INC. (US) 2017-01-05 WO disclosed
EP-2819688-A1 TRIAZOLE-CROSSLINKED AND THIOETHER-CROSSLINKED PEPTIDOMIMETIC MACROCYCLES Aileron Therapeutics, Inc. (US) 2015-01-07 EP disclosed
WO-2013123267-A1 TRIAZOLE-CROSSLINKED AND THIOETHER-CROSSLINKED PEPTIDOMIMETIC MACROCYCLES AILERON THERAPEUTICS, INC. (US) 2013-08-22 WO disclosed
WO-2012173846-A2 PEPTIDOMIMETIC MACROCYCLES AILERON THERAPEUTICS, INC. (US) 2012-12-20 WO disclosed
EP-2488193-A1 IMPROVED PEPTIDOMIMETIC MACROCYCLES Aileron Therapeutics, Inc. (US) 2012-08-22 EP disclosed
EP-2480565-A1 PEPTIDOMIMETIC MACROCYCLES Aileron Therapeutics, Inc. (US) 2012-08-01 EP disclosed
WO-2012021874-A1 PEPTIDOMIMETIC MACROCYCLES WITH THIOETHER LINKERS AILERON THERAPEUTICS, INC. (US) 2012-02-16 WO disclosed
EP-2376100-A2 PEPTIDOMIMETIC MACROCYCLES Aileron Therapeutics, Inc. (US) 2011-10-19 EP disclosed
EP-2331567-A1 PEPTIDOMIMETIC MACROCYCLES Aileron Therapeutics, Inc. (US) 2011-06-15 EP disclosed
EP-2329015-A1 PEPTIDOMIMETIC MACROCYCLES Aileron Therapeutics, Inc. (US) 2011-06-08 EP disclosed
WO-2011047215-A1 IMPROVED PEPTIDOMIMETIC MACROCYCLES AILERON THERAPEUTICS, INC. (US) 2011-04-21 WO disclosed
WO-2011038049-A1 PEPTIDOMIMETIC MACROCYCLES AILERON THERAPEUTICS, INC. (US) 2011-03-31 WO disclosed
EP-2242503-A2 THERAPEUTIC PEPTIDOMIMETIC MACROCYCLES Aileron Therapeutics, Inc. (US) 2010-10-27 EP disclosed
WO-2010083347-A2 PEPTIDOMIMETIC MACROCYCLES AILERON THERAPEUTICS, INC. (US) 2010-07-22 WO disclosed
WO-2010034029-A1 PEPTIDOMIMETIC MACROCYCLES AILERON THERAPEUTICS, INC. (US) 2010-03-25 WO disclosed
WO-2010034026-A1 PEPTIDOMIMETIC MACROCYCLES AILERON THERAPEUTICS, INC. (US) 2010-03-25 WO disclosed
WO-2009099677-A2 THERAPEUTIC PEPTIDOMIMETIC MACROCYCLES AILERON THERAPEUTICS, INC. (US) 2009-08-13 WO disclosed