Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.47 |
| ▸ | IDO1 | P14902 | 2/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.43 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.43 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.43 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA5A | P35218 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6237592 | 0.83 | MAOB (0.40) | HTR1AADRA1DADRA1AADRA1BALDH1A1 | |
| SCHEMBL4556504 | 0.83 | MTNR1A (0.61) | MTNR1AMTNR1BALDH1A1HPGDCA12 | |
| SCHEMBL6244574 | 0.81 | IDO1 (0.44) | HTR1AADRA1DADRA1AADRA1BIDO1 | |
| SCHEMBL6234787 | 0.80 | CHRM2 (0.57) | HTR1AADRA1DADRA1AADRA1BIDO1 | |
| SCHEMBL1255872 | 0.80 | NPSR1 (0.56) | NPSR1ALDH1A1HPGDBCHECHRM2 | |
| SCHEMBL6239312 | 0.77 | SMN1; SMN2 (0.52) | HTR1AADRA1DADRA1AADRA1BPARP10 | |
| SCHEMBL6237989 | 0.74 | IDO1 (0.49) | HTR1AADRA1DADRA1AADRA1BIDO1 | |
| SCHEMBL9776122 | 0.73 | MTNR1A (0.49) | MTNR1AMTNR1BNPSR1ALDH1A1CA12 | |
| SCHEMBL9776051 | 0.73 | MTNR1A (0.49) | MTNR1AMTNR1BNPSR1ALDH1A1CA12 | |
| SCHEMBL9776110 | 0.73 | MTNR1A (0.49) | MTNR1AMTNR1BNPSR1ALDH1A1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005011697-A2 | SULFONAMIDE DERIVATIVES WITH ACTIVITY ON PROTEIN KINASE A AND B | ASTEX THERAPEUTICS LIMITED (GB) | 2005-02-10 | — | — | WO | disclosed |