Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.49 |
| ▸ | AGXT | P21549 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.46 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.46 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5099389 | 0.82 | MTNR1A (0.65) | MEN1KMT2AALDH1A1KDM4EMTNR1A | |
| SCHEMBL6240427 | 0.82 | CYP3A4 (0.46) | IDO1AGXTALDH1A1KDM4EHTR1A | |
| SCHEMBL6237993 | 0.81 | CHRM2 (0.55) | IDO1AGXTMEN1KMT2AALDH1A1 | |
| SCHEMBL4584070 | 0.81 | MEN1 (0.65) | MEN1KMT2AALDH1A1KDM4EHTT | |
| SCHEMBL6239312 | 0.81 | SMN1; SMN2 (0.52) | MEN1KMT2AHTTSMN1; SMN2HTR1A | |
| SCHEMBL6239811 | 0.80 | SIRT2 (0.49) | MEN1KMT2AALDH1A1TSHR | |
| SCHEMBL17072667 | 0.76 | KDM4E (0.59) | ALDH1A1KDM4ESMN1; SMN2SPHK2SPHK1 | |
| SCHEMBL6237705 | 0.75 | RAB9A (0.45) | AGXTALDH1A1HTTSMN1; SMN2SPHK2 | |
| SCHEMBL6235212 | 0.75 | IDO1 (0.45) | IDO1MEN1KMT2ASMN1; SMN2TSHR | |
| SCHEMBL2970007 | 0.74 | IDO1 (0.59) | IDO1AGXT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005011697-A2 | SULFONAMIDE DERIVATIVES WITH ACTIVITY ON PROTEIN KINASE A AND B | ASTEX THERAPEUTICS LIMITED (GB) | 2005-02-10 | — | — | WO | disclosed |