SCHEMBL6239312

SCHEMBL6239312

NC(=O)CNCCOCc1ccccc1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.52
HTT P42858 1/20 0.52
SPHK2 Q9NRA0 2/20 0.51
SPHK1 Q9NYA1 1/20 0.51
LMNA P02545 1/20 0.50
TSHR P16473 1/20 0.44
ASAH1 Q13510 1/20 0.43
NPC1 O15118 1/20 0.42
RAB9A P51151 1/20 0.42
HTR1A P08908 1/20 0.41
ADRA1D P25100 1/20 0.41
ADRA1A P35348 1/20 0.41
ADRA1B P35368 1/20 0.41
SLC1A3 P43003 2/20 0.41
SLC1A2 P43004 2/20 0.41
SLC1A1 P43005 2/20 0.41
MEN1 O00255 1/20 0.41
CYP1A2 P05177 1/20 0.41
CYP2D6 P10635 1/20 0.41
CYP2C9 P11712 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Trifluoroacetic Acid SCHEMBL7760506 0.92 SMN1; SMN2 (0.46) SMN1; SMN2HTTSPHK2SPHK1LMNA
SCHEMBL880293 0.87 SMN1; SMN2 (0.55) SMN1; SMN2HTTLMNATSHRASAH1
SCHEMBL6237705 0.84 RAB9A (0.45) SMN1; SMN2HTTSPHK2SPHK1NPC1
SCHEMBL6237097 0.84 LMNA (0.48) SPHK2SPHK1LMNANPC1RAB9A
SCHEMBL6240427 0.83 CYP3A4 (0.46) SPHK2SPHK1TSHRHTR1AADRA1D
SCHEMBL20221617 0.83 SMN1; SMN2 (0.51) SMN1; SMN2HTTLMNATSHRASAH1
SCHEMBL6237989 0.81 IDO1 (0.49) SMN1; SMN2HTTSPHK2SPHK1TSHR
SCHEMBL8760726 0.80 TSHR (0.61) SMN1; SMN2HTTLMNATSHRHTR1A
SCHEMBL28906679 0.80 LMNA (0.54) SMN1; SMN2HTTLMNATSHRASAH1
SCHEMBL8604263 0.80 SMN1; SMN2 (0.63) SMN1; SMN2HTTLMNATSHRASAH1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2005011697-A2 SULFONAMIDE DERIVATIVES WITH ACTIVITY ON PROTEIN KINASE A AND B ASTEX THERAPEUTICS LIMITED (GB) 2005-02-10 WO claimed
WO-2005011697-A2 SULFONAMIDE DERIVATIVES WITH ACTIVITY ON PROTEIN KINASE A AND B ASTEX THERAPEUTICS LIMITED (GB) 2005-02-10 WO disclosed