Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADK | P55263 | 9/20 | 0.69 |
| ▸ | HTR2B | P41595 | 5/20 | 0.59 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.59 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.59 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.59 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.59 |
| ▸ | HTR6 | P50406 | 1/20 | 0.59 |
| ▸ | SLC29A1 | Q99808 | 2/20 | 0.59 |
| ▸ | HTR1D | P28221 | 1/20 | 0.56 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.51 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.51 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.51 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8331350 | 1.00 | ADK (0.69) | ADKHTR2BSIGMAR1TMEM97ADRA2C | |
| SCHEMBL8333496 | 0.88 | ADK (0.71) | ADKHTR2BSIGMAR1TMEM97ADRA2C | |
| Hydrochloric Acid SCHEMBL6234279 | 0.87 | ADK (0.77) | ADK | |
| SCHEMBL8327965 | 0.85 | ADK (0.69) | ADKHTR2BSIGMAR1TMEM97ADRA2C | |
| SCHEMBL8975497 | 0.84 | ADORA3 (0.71) | ADKHTR2BSIGMAR1TMEM97ADRA2C | |
| SCHEMBL6765375 | 0.82 | ADORA3 (0.77) | SLC29A1ADORA3TP53TDP1PAX8 | |
| SCHEMBL8975040 | 0.82 | ADK (1.00) | ADKSLC29A1 | |
| SCHEMBL8332497 | 0.82 | ADK (1.00) | ADKSLC29A1 | |
| SCHEMBL31617931 | 0.80 | ADK (1.00) | ADKSLC29A1TP53PAX8 | |
| SCHEMBL17800832 | 0.80 | ADK (1.00) | ADKSLC29A1TP53PAX8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0836613-B1 | WATER-SOLUBLE ADENOSINE KINASE INHIBITORS | METABASIS THERAPEUTICS INC (US) | 2005-05-25 | — | — | EP | disclosed |
| US-5795977-A | Water soluble adenosine kinase inhibitors | METABASIS THERAPEUTICS, INC. (US) | 1998-08-18 | — | — | US | disclosed |
| EP-0836613-A1 | WATER-SOLUBLE ADENOSINE KINASE INHIBITORS | GENSIA, INC. (US) | 1998-04-22 | — | — | EP | disclosed |
| US-5726302-A | SUBSTITUTED 4-AMINO PYRROLO(2,3-D) PYRIMIDINE AND PYRAZOLO(3,4-D) PYRIMIDINE NUCLEOSIDE ANALOGS | GENSIA INC. (US) | 1998-03-10 | — | — | US | disclosed |
| WO-1996040707-A1 | WATER-SOLUBLE ADENOSINE KINASE INHIBITORS | GENSIA SICOR (US) | 1996-12-19 | — | — | WO | disclosed |