Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCAM1 | P19320 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.44 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.44 |
| ▸ | GRIA3 | P42263 | 2/20 | 0.44 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.44 |
| ▸ | GRM6 | O15303 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | APEX1 | P27695 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3921931 | 0.87 | VCAM1 (0.58) | VCAM1MAPTGRIA1GRIA2GRIA3 | |
| SCHEMBL9798297 | 0.84 | VCAM1 (0.39) | VCAM1MAPTGRIA1GRIA2GRIA3 | |
| SCHEMBL9798291 | 0.84 | VCAM1 (0.39) | VCAM1MAPTGRIA1GRIA2GRIA3 | |
| SCHEMBL16956496 | 0.83 | VCAM1 (0.46) | VCAM1MAPTGRIA1GRIA2GRIA3 | |
| SCHEMBL29151814 | 0.82 | GRIA1 (0.46) | VCAM1MAPTGRIA1GRIA2GRIA3 | |
| SCHEMBL855859 | 0.81 | VCAM1 (0.42) | VCAM1MAPTGRIA1GRIA2GRIA3 | |
| SCHEMBL22664328 | 0.80 | VCAM1 (0.43) | VCAM1MAPTGRIA1GRIA2GRIA3 | |
| SCHEMBL29100217 | 0.78 | VCAM1 (0.45) | VCAM1MAPTGRIA1GRIA2GRIA3 | |
| SCHEMBL1117240 | 0.78 | TSHR (0.50) | MAPTGRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL1372821 | 0.78 | ALDH1A1 (0.40) | VCAM1MAPTGRIA1GRIA2GRIA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110081338-A1 | METABOLICALLY INERT ANTIFOLATES FOR TREATING DISORDERS OF ABNORMAL CELLULAR PROLIFERATION AND INFLAMMATION | CHELSEA THERAPEUTICS, INC. | 2011-04-07 | — | — | US | disclosed |
| US-20110082149-A1 | METABOLICALLY INERT ANTIFOLATES FOR TREATING DISORDERS OF ABNORMAL CELLULAR PROLIFERATION AND INFLAMMATION | CHELSEA THERAPEUTICS, INC. | 2011-04-07 | — | — | US | disclosed |
| EP-1535911-A1 | Metabolically inert anti-inflammatory and anti-tumor antifolates | NAIR, Madhavan G. (US) | 2005-06-01 | — | — | EP | disclosed |
| EP-1062209-A4 | METABOLICALLY INERT ANTI-INFLAMMATORY AND ANTI-TUMOR ANTIFOLATES | NAIR MADHAVAN G (US) | 2002-02-27 | — | — | EP | disclosed |
| EP-1062209-A1 | METABOLICALLY INERT ANTI-INFLAMMATORY AND ANTI-TUMOR ANTIFOLATES | NAIR, Madhavan G. (US) | 2000-12-27 | — | — | EP | disclosed |
| WO-1999036409-A1 | METABOLICALLY INERT ANTI-INFLAMMATORY AND ANTI-TUMOR ANTIFOLATES | NAIR MADHAVAN G (US) | 1999-07-22 | — | — | WO | disclosed |
| US-5912251-A | ENZYME INHIBITORS | CHELSEA THERAPEUTICS, INC. | 1999-06-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110081338-A1 | METABOLICALLY INERT ANTIFOLATES FOR TREATING DISORDERS OF ABNORMAL CELLULAR PROLIFERATION AND INFLAMMATION | DHFR, MTHFD1, MTHFD2 | VCAM1 1416/4885MAPT 816/4885GRIA1 3613/4885 |
| US-20110082149-A1 | METABOLICALLY INERT ANTIFOLATES FOR TREATING DISORDERS OF ABNORMAL CELLULAR PROLIFERATION AND INFLAMMATION | DHFR, MTHFD1, MTHFD2 | VCAM1 1416/4885MAPT 816/4885GRIA1 3613/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.