SCHEMBL6236956

SCHEMBL6236956

COc1ccc(-c2cc(C3=C(c4c(C)sc(-c5ccc(C)cc5)c4C)C(F)(F)C(F)(F)C3(F)F)c(C)s2)cc1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 2/20 0.36
APP P05067 4/20 0.33
GRM6 O15303 1/20 0.33
ACHE P22303 1/20 0.31
EGFR P00533 1/20 0.31
KDR P35968 1/20 0.31
IKBKB O14920 1/20 0.31
PDGFRB P09619 1/20 0.31
KIT P10721 1/20 0.31
MAPT P10636 3/20 0.31
NPC1 O15118 2/20 0.31
ALDH1A1 P00352 2/20 0.31
TP53 P04637 2/20 0.31
HPGD P15428 2/20 0.31
RAB9A P51151 2/20 0.31
HSD17B10 Q99714 2/20 0.31
KDM4E B2RXH2 1/20 0.31
MEN1 O00255 1/20 0.31
CASP3 P42574 1/20 0.31
KMT2A Q03164 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3858306 0.97 APP (0.35) ALOX5APPGRM6IKBKBPDGFRB
SCHEMBL3851690 0.92 ESR1 (0.30)
SCHEMBL20089651 0.89 APP (0.41) ALOX5APPACHEEGFRKDR
SCHEMBL2990966 0.85 APP (0.45) APPIKBKBPDGFRBKITMAPT
SCHEMBL3852637 0.85 GRM6 (0.41) ALOX5APPGRM6MAPTALDH1A1
SCHEMBL3855828 0.83 PLA2G10 (0.34) NPC1ALDH1A1HPGDRAB9ASMN1; SMN2
SCHEMBL27559291 0.82
SCHEMBL5466664 0.80 ESR1 (0.36)
SCHEMBL15926425 0.80 APP (0.40) APPIKBKBPDGFRBKITMAPT
SCHEMBL9033357 0.79 GCGR (0.39) APPPDGFRBKITMAPTNPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3732533-B1 SYSTEM AND METHOD FOR CUSTOMIZATION OF A PHOTOCHROMIC ARTICLE TRANSITIONS OPTICAL LTD (IE) 2025-12-10 EP disclosed
US-11609442-B2 System and method for customization of a photochromic article TRANSITIONS OPTICAL, LTD. (IE) 2023-03-21 US disclosed
US-20210055575-A1 System and Method for Customization of a Photochromic Article TRANSITIONS OPTICAL, LTD. (IE) 2021-02-25 US disclosed
EP-3732533-A1 SYSTEM AND METHOD FOR CUSTOMIZATION OF A PHOTOCHROMIC ARTICLE Transitions Optical, Ltd. (IE) 2020-11-04 EP disclosed
CN-111527442-A System and method for customizing photochromic articles 光学转变有限公司 2020-08-11 CN disclosed
US-8444450-B2 Method for alternately expressing color-memorizing photochromic function in toy element, and an alternately color-memorizing photochromic toy THE PILOT INK CO., LTD. (JP) 2013-05-21 US disclosed
EP-1415692-B1 Method of changing color of a toy and colour changing toy PILOT INK CO LTD (JP) 2005-05-04 EP disclosed
US-20040135097-A1 Method for alternately expressing color-memorizing photochromic function in toy element, and an alternately color-memorizing photochromic toy THE PILOT INK CO., LTD. 2004-07-15 US disclosed
EP-1415692-A1 Method of changing color of a toy and colour changing toy THE PILOT INK CO., LTD. (JP) 2004-05-06 EP disclosed