SCHEMBL3858306

SCHEMBL3858306

COc1ccc(-c2cc(C3=C(c4c(C)sc(-c5ccc(OC)cc5)c4C)C(F)(F)C(F)(F)C3(F)F)c(C)s2)cc1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
APP P05067 5/20 0.35
GRM6 O15303 1/20 0.34
IKBKB O14920 1/20 0.33
NPC1 O15118 3/20 0.32
RAB9A P51151 3/20 0.32
KMT2A Q03164 3/20 0.32
ALDH1A1 P00352 2/20 0.32
TP53 P04637 2/20 0.32
MAPT P10636 2/20 0.32
HPGD P15428 2/20 0.32
HSD17B10 Q99714 2/20 0.32
MEN1 O00255 2/20 0.32
PDGFRB P09619 1/20 0.32
KIT P10721 1/20 0.32
KDM4E B2RXH2 1/20 0.32
CASP3 P42574 1/20 0.32
SENP8 Q96LD8 1/20 0.32
SENP7 Q9BQF6 1/20 0.32
SENP6 Q9GZR1 1/20 0.32
ALOX15 P16050 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6236956 0.97 ALOX5 (0.36) APPGRM6IKBKBNPC1RAB9A
SCHEMBL27537459 0.93 GRM6 (0.35) APPGRM6IKBKBNPC1RAB9A
SCHEMBL3851690 0.89 ESR1 (0.30)
SCHEMBL2990966 0.88 APP (0.45) APPIKBKBNPC1RAB9AKMT2A
SCHEMBL3852637 0.88 GRM6 (0.41) APPGRM6ALDH1A1MAPTHPGD
SCHEMBL3855828 0.86 PLA2G10 (0.34) NPC1RAB9AALDH1A1HPGDSMN1; SMN2
SCHEMBL20089651 0.85 APP (0.41) APPIKBKBNPC1RAB9AKMT2A
SCHEMBL15926425 0.82 APP (0.40) APPIKBKBNPC1RAB9AKMT2A
SCHEMBL9033357 0.81 GCGR (0.39) APPNPC1RAB9AKMT2AALDH1A1
SCHEMBL9034121 0.81 APP (0.41) APPIKBKBNPC1RAB9AKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7575386-B2 Color-memorizing photochromic writing instrument, color-memorizing photochromic writing instrument set using the same and method for alternately expressing color-memorizing photochromic function of writing image THE PILOT INK CO., LTD. (JP) 2009-08-18 US disclosed
US-20070082977-A1 Ink composition for color-memorizing photochromic writing instrument and writing instrument using the same THE PILOT INK CO., LTD. 2007-04-12 US disclosed
US-20060053975-A1 Color-memorizing photochromic writing instrument, color-memorizing photochromic writing instrument set using the same and method for alternately expressing color-memorizing photochromic function of writing image THE PILOT INK CO., LTD. 2006-03-16 US disclosed