SCHEMBL2990966

SCHEMBL2990966

COc1ccc(-c2cc(C3=C(c4cc(-c5ccc(OC)cc5)sc4C)C(F)(F)C(F)(F)C3(F)F)c(C)s2)cc1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
APP P05067 5/20 0.45
IKBKB O14920 2/20 0.40
NPC1 O15118 4/20 0.39
RAB9A P51151 4/20 0.39
ALDH1A1 P00352 3/20 0.39
HPGD P15428 3/20 0.39
TP53 P04637 2/20 0.39
MAPT P10636 2/20 0.39
HSD17B10 Q99714 2/20 0.39
ALOX15 P16050 1/20 0.39
TSHR P16473 1/20 0.39
NFKB1 P19838 1/20 0.39
MAPK1 P28482 1/20 0.39
NFKB2 Q00653 1/20 0.39
RELA Q04206 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
KMT2A Q03164 3/20 0.39
MEN1 O00255 2/20 0.39
PGR P06401 1/20 0.39
ADRB2 P07550 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20089651 0.96 APP (0.41) APPIKBKBNPC1RAB9AALDH1A1
SCHEMBL15926425 0.94 APP (0.40) APPIKBKBNPC1RAB9AALDH1A1
SCHEMBL9033357 0.92 GCGR (0.39) APPNPC1RAB9AALDH1A1HPGD
SCHEMBL9034121 0.92 APP (0.41) APPIKBKBNPC1RAB9AALDH1A1
SCHEMBL13163334 0.90 APP (0.43) APPIKBKBNPC1RAB9AALDH1A1
SCHEMBL13164320 0.89 BACE1 (0.44) APPIKBKBNPC1RAB9AALDH1A1
SCHEMBL3858306 0.88 APP (0.35) APPIKBKBNPC1RAB9AALDH1A1
SCHEMBL10002013 0.86 APP (0.45) APPIKBKBNPC1RAB9AALDH1A1
SCHEMBL10101123 0.86 APP (0.45) APPIKBKBNPC1RAB9AALDH1A1
SCHEMBL6236956 0.85 ALOX5 (0.36) APPIKBKBNPC1RAB9AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090325078-A1 HOLOGRAPHIC RECORDING MEDIUM GENERAL ELECTRIC COMPANY (US) 2009-12-31 US claimed
US-20070146835-A1 Methods for making holographic data storage articles GENERAL ELECTRIC COMPANY (US) 2007-06-28 US claimed
US-9109131-B2 Photochromic phase change ink compositions XEROX CORPORATION (US) 2015-08-18 US disclosed
US-9109131-B2 Photochromic phase change ink compositions XEROX CORPORATION (US) 2015-08-18 US disclosed
US-7794896-B2 Methods for making holographic data storage articles GENERAL ELECTRIC COMPANY (US) 2010-09-14 US disclosed
US-7794896-B2 Methods for making holographic data storage articles GENERAL ELECTRIC COMPANY (US) 2010-09-14 US disclosed
US-20100180937-A1 HOLOGRAPHIC ENERGY-COLLECTING MEDIUM AND ASSOCIATED DEVICE GENERAL ELECTRIC COMPANY (US) 2010-07-22 US disclosed
US-20090325078-A1 HOLOGRAPHIC RECORDING MEDIUM GENERAL ELECTRIC COMPANY (US) 2009-12-31 US disclosed
US-20090325078-A1 HOLOGRAPHIC RECORDING MEDIUM GENERAL ELECTRIC COMPANY (US) 2009-12-31 US disclosed
US-20080055686-A1 Holographic data recording method and system SABIC INNOVATIVE PLASTICS IP B.V. 2008-03-06 US disclosed
US-20080055686-A1 Holographic data recording method and system SABIC INNOVATIVE PLASTICS IP B.V. 2008-03-06 US disclosed
US-20070146835-A1 Methods for making holographic data storage articles GENERAL ELECTRIC COMPANY (US) 2007-06-28 US disclosed
US-20070146835-A1 Methods for making holographic data storage articles GENERAL ELECTRIC COMPANY (US) 2007-06-28 US disclosed
US-20070113358-A1 Active and adaptive photochromic fibers, textiles and membranes UNIVERSITY OF DELAWARE (US) 2007-05-24 US disclosed
WO-2007050354-A2 METHODS FOR MAKING HOLOGRAPHIC DATA STORAGE ARTICLES GENERAL ELECTRIC COMPANY (US) 2007-05-03 WO disclosed
US-20070097469-A1 Methods for making holographic data storage articles GENERAL ELECTRIC COMPANY (US) 2007-05-03 US disclosed
US-20070097469-A1 Methods for making holographic data storage articles GENERAL ELECTRIC COMPANY (US) 2007-05-03 US disclosed
US-7157518-B2 Method for preparing an organo-silicon sol and materials obtained from such a sol ESSILOR INTERNATIONAL COMPAGNIE GENERALE D'OPTIQUE (FR) 2007-01-02 US disclosed
US-7157518-B2 Method for preparing an organo-silicon sol and materials obtained from such a sol ESSILOR INTERNATIONAL COMPAGNIE GENERALE D'OPTIQUE (FR) 2007-01-02 US disclosed