SCHEMBL3852637

SCHEMBL3852637

COc1ccc(-c2sc(C)c(C3=C(c4c(C)sc(-c5ccc(OC)cc5)c4C)C(F)(F)C(F)(F)C3(F)F)c2C)cc1

nearest known ligand 0.41

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
GRM6 O15303 1/20 0.41
PTGS2 P35354 3/20 0.39
ALOX5 P09917 4/20 0.38
APP P05067 4/20 0.38
ALDH1A1 P00352 2/20 0.37
HPGD P15428 1/20 0.37
KDM4E B2RXH2 1/20 0.35
MAPT P10636 1/20 0.35
OPRD1 P41143 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3858306 0.88 APP (0.35) GRM6PTGS2ALOX5APPALDH1A1
SCHEMBL6236956 0.85 ALOX5 (0.36) GRM6ALOX5APPALDH1A1HPGD
SCHEMBL9574524 0.84 GAA (0.43) ALDH1A1HPGDKDM4EMAPT
SCHEMBL1043494 0.82 GRM6 (0.36) GRM6ALOX5ALDH1A1HPGDKDM4E
SCHEMBL9045738 0.77 ALDH1A1 (0.37) PTGS2ALDH1A1HPGDKDM4EMAPT
SCHEMBL3851157 0.76 RELA (0.43) PTGS2ALOX5ALDH1A1HPGDKDM4E
SCHEMBL20702041 0.75 GRM6 (0.34) GRM6ALOX5ALDH1A1HPGDKDM4E
SCHEMBL13731764 0.74 APP (0.50) GRM6PTGS2ALOX5APPALDH1A1
SCHEMBL3851690 0.74 ESR1 (0.30)
SCHEMBL10002013 0.71 APP (0.45) PTGS2APPALDH1A1HPGDKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-7173151-A None JP disclosed
EP-3732533-B1 SYSTEM AND METHOD FOR CUSTOMIZATION OF A PHOTOCHROMIC ARTICLE TRANSITIONS OPTICAL LTD (IE) 2025-12-10 EP disclosed
US-11609442-B2 System and method for customization of a photochromic article TRANSITIONS OPTICAL, LTD. (IE) 2023-03-21 US disclosed
US-20210055575-A1 System and Method for Customization of a Photochromic Article TRANSITIONS OPTICAL, LTD. (IE) 2021-02-25 US disclosed
EP-3732533-A1 SYSTEM AND METHOD FOR CUSTOMIZATION OF A PHOTOCHROMIC ARTICLE Transitions Optical, Ltd. (IE) 2020-11-04 EP disclosed
US-8444450-B2 Method for alternately expressing color-memorizing photochromic function in toy element, and an alternately color-memorizing photochromic toy THE PILOT INK CO., LTD. (JP) 2013-05-21 US disclosed
US-7575386-B2 Color-memorizing photochromic writing instrument, color-memorizing photochromic writing instrument set using the same and method for alternately expressing color-memorizing photochromic function of writing image THE PILOT INK CO., LTD. (JP) 2009-08-18 US disclosed
EP-1637570-B1 Color-memorizing photochromic writing instrument PILOT INK CO LTD (JP) 2007-06-27 EP disclosed
US-20070082977-A1 Ink composition for color-memorizing photochromic writing instrument and writing instrument using the same THE PILOT INK CO., LTD. 2007-04-12 US disclosed
EP-1637570-A1 Color-memorizing photochromic writing instrument THE PILOT INK CO., LTD. (JP) 2006-03-22 EP disclosed
US-20060053975-A1 Color-memorizing photochromic writing instrument, color-memorizing photochromic writing instrument set using the same and method for alternately expressing color-memorizing photochromic function of writing image THE PILOT INK CO., LTD. 2006-03-16 US disclosed
EP-1415692-B1 Method of changing color of a toy and colour changing toy PILOT INK CO LTD (JP) 2005-05-04 EP disclosed
US-20040135097-A1 Method for alternately expressing color-memorizing photochromic function in toy element, and an alternately color-memorizing photochromic toy THE PILOT INK CO., LTD. 2004-07-15 US disclosed
EP-1415692-A1 Method of changing color of a toy and colour changing toy THE PILOT INK CO., LTD. (JP) 2004-05-06 EP disclosed
JP-H07173151-A DIARYLETHENE-BASED COMPOUND AND OPTICAL RECORDING-REGENERATION OF OPTICAL RECORDING MEDIUM CONTAINING THE SAME COMPOUND KANEBO LTD 1995-07-11 JP disclosed