Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.49 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | CDK4 | P11802 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.43 |
| ▸ | FLT1 | P17948 | 2/20 | 0.42 |
| ▸ | DHODH | Q02127 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
| ▸ | ARNT | P27540 | 1/20 | 0.41 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.41 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.40 |
| ▸ | RAF1 | P04049 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6240725 | 0.84 | TDO2 (0.51) | GRM4KDR | |
| SCHEMBL30041659 | 0.77 | EPHX2 (0.48) | KDRCDK2FLT1DHODH | |
| SCHEMBL6237657 | 0.75 | AURKA (0.57) | RAPGEF4GRM4MEN1KMT2AALDH1A1 | |
| SCHEMBL15522254 | 0.74 | RAPGEF4 (0.49) | RAPGEF4GRM4KDRMEN1KMT2A | |
| SCHEMBL6231959 | 0.74 | RAPGEF4 (0.49) | RAPGEF4GRM4 | |
| SCHEMBL13524613 | 0.72 | GSK3B (0.55) | RAPGEF4GRM4KDRMEN1KMT2A | |
| SCHEMBL6233705 | 0.71 | NOTUM (0.40) | ALDH1A1DHODH | |
| SCHEMBL11375683 | 0.70 | NPC1 (0.56) | RAPGEF4GRM4KDRMEN1KMT2A | |
| SCHEMBL28744365 | 0.70 | RAPGEF4 (0.58) | RAPGEF4GRM4KDRMEN1KMT2A | |
| SCHEMBL91480 | 0.70 | CDK4 (0.49) | RAPGEF4GRM4CDK4CDK2DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005005382-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | CYTOKINETICS, INC. (US) | 2005-01-20 | — | — | WO | disclosed |